Residual Solvents Market Size To Reach $2.00 Billion By 2030

Residual Solvents Market Growth & Trends

The global residual solvents market size is anticipated to reach USD 2.00 billion by 2030, registering a CAGR of 5.0% from 2025 to 2030, according to a new report by Grand View Research, Inc. The expansion of the pharmaceutical and biotechnology industries, particularly in drug formulation, API manufacturing, and biologics, increases the demand for solvent testing. Additionally, growing consumer awareness and quality standards in cosmetics and food safety further propel market growth. Technological advancements in gas chromatography (GC) and mass spectrometry (GC-MS) enhance detection accuracy, driving adoption.

The class 2 segment dominated the residual solvents industry with a revenue share of 38.9% in 2024, during the forecast period. Class 2 residual solvents are solvents with moderate toxicity that must be limited in pharmaceutical, food, and cosmetic products to ensure safety. Examples include methanol, toluene, and dichloromethane, which are commonly used in manufacturing but require strict regulation under ICH guidelines to minimize health risks.

The pharmaceuticals segment dominated the market with a revenue share of 58.3% in 2024, during the forecast period. The pharmaceutical segment dominated due to the extensive use of solvents in drug synthesis, formulation, and purification. Regulatory bodies like the FDA, ICH, and EMA enforce strict solvent limits to ensure drug safety and compliance. Advanced analytical techniques such as gas chromatography (GC) and mass spectrometry (GC-MS) are widely used for solvent detection in pharmaceutical manufacturing.

North America dominated the market with a market share of 54.34% in 2024, during the forecast period. The region's well-established pharmaceutical and biotechnology industries, along with advancements in analytical technologies like gas chromatography (GC) and mass spectrometry (GC-MS), drive market growth. Additionally, increasing consumer awareness, demand for high-purity products, and the presence of leading analytical instrument manufacturers further boost the market.

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Residual Solvents Market Report Highlights

• The class 2 segment is held the largest revenue share of 38.9% in 2024.The Class 2 segment held the largest share due to the moderate toxicity of these solvents, requiring strict regulation in pharmaceuticals, food, and cosmetics. Solvents like toluene, methanol, and dichloromethane are widely used but must comply with ICH-permissible daily exposure (PDE) limits to ensure product safety.

• North America was the dominant region for the residual solvents industry with a revenue share of 54.34% in 2024. North America led the market due to strict regulatory standards from the FDA, USP, and ICH, ensuring safety in pharmaceuticals, food, and cosmetics. The region's strong pharmaceutical sector and advancements in analytical technologies further drive market growth.

• In March 2023, The United States Pharmacopeia (USP) has revised Chapter <467> "Residual Solvents" to align with the updated ICH guideline Q3C (R8) on impurities. This revision introduces two Class 2 solvents, cyclopentyl methyl ether and tertiary butyl alcohol, and one Class 3 solvent, 2-methyltetrahydrofuran, necessitating updates to related sections and appendices.

Residual Solvents Market Segmentation

Grand View Research has segmented the global residual solvents market based on type, application, and region:

Residual Solvents Type Outlook (Volume, Kilotons; Revenue, USD Billion, 2018 - 2030)

• Class 1

• Class 2

• Class 3

Residual Solvents Application Outlook (Volume, Kilotons; Revenue, USD Billion, 2018 - 2030)

• Pharmaceuticals

• Food & Beverages

• Cosmetics

• Industrial

Residual Solvents Regional Outlook (Volume, Kilotons; Revenue, USD Billion, 2018 - 2030)

• North America

  • U.S.

  • Canada

  • Mexico

• Europe

  • Germany

  • UK

  • France

  • Italy

  • Spain

• Asia Pacific

  • China

  • India

  • Japan

  • South Korea

• Latin America

  • Brazil

  • Argentina

• Middle East & Africa

  • Saudi Arabia

  • South Africa

List of Key Players in Residual Solvents Market

• Agilent Technology

• Shimadzu

• PerkinElmer

• Thermo Fisher Scientific

• Bruker

• Techcomp

• LECO

• Fuli Instruments

• Beifenruili