Naltrexone And Buprenorphine Market To Reach $9.80 Billion By 2033

Naltrexone And Buprenorphine Market Growth & Trends

The global naltrexone and buprenorphine market size is expected to reach USD 9.80 billion by 2033, registering a CAGR of 9.25% from 2025 to 2033, according to a new report by Grand View Research, Inc. The market is experiencing growth primarily due to the rising incidence of substance use disorders, increasing government efforts to address the crisis, and growing awareness of treatments for opioid use disorder. These factors are anticipated to substantially boost industry expansion during the forecast period, fostering advancements and improving accessibility to addiction care solutions. 

The World Drug Report 2023 highlights global trends in drug use disorders, emphasizing opioids as the primary cause of death from overdose and significant contributors to years lost due to disability and premature death. Opioid Use Disorder (OUD) affects millions worldwide, with disparities in treatment access exacerbated by the COVID-19 pandemic. Regional variations in primary drugs of abuse include opioids in Europe and Asia, cocaine in Latin America, and methamphetamine in East & Southeast Asia. Stigma and discrimination hinder treatment efforts, with less than 20% of those needing help receiving it. The report calls for international cooperation to address these complex health and societal challenges. 

Furthermore, increasing government initiatives to combat the OUD crisis through multifaceted approaches are growing. In February 2024, with the approval of the SAMHSA, USD 46.6 million in supplemental Community Mental Health Services Block Grant and Substance Use Prevention, Treatment, and Recovery Services Block Grant funds have been allocated to mental health and substance use services. In addition, USD 67.5 million from U.S. Department of Treasury funds has been directed to support these efforts in Wisconsin. 

Moreover, industry players are driving growth in the market through strategic initiatives, such as enhanced distribution networks, strategic partnerships with healthcare providers, and increased research and development investments. For instance, in July 2023, Titan Pharmaceuticals, Inc. and Fedson, Inc. signed an Asset Purchase Agreement, under which Titan would sell part of ProNeura assets, such as its portfolio of medications for drug addiction and other early development initiatives built on the ProNeura drug delivery technology. The company's addiction portfolio comprised implant programs for Nalmefene and Probuphine. In addition, in September 2023, Camurus AB introduced Brixadi, a weekly and monthly medication containing Brixadi, indicated to treat moderate-to-severe OUD. These efforts aim to expand treatment accessibility and efficacy, propelling advancement significantly. 

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Naltrexone And Buprenorphine Market Report Highlights

• The buprenorphine segment dominated the market with the largest revenue share of 73.5% in 2024. The naltrexone segment is projected to grow at a significant CAGR of 2.20% over the forecast period.

• The injectable segment accounted for the largest share of 68.1% of the market in 2024.The naltrexone segment is categorized into oral, injectable, and implantable administration forms.

• The OUD application generated the highest revenue share of 69.5% in 2024.The Opioid Use Disorder (OUD) application in the buprenorphine segment accounted for the largest share of the global market in 2024.

• Hospital pharmacies dominated the market with a revenue share of 47.9% in 2024. The retail pharmacies segment is expected to experience significant growth over the forecast period.

• North America naltrexone and buprenorphine market held the largest revenue share of 39.4% in 2024. The Asia Pacific naltrexone and buprenorphine market is expected to register the fastest CAGR of 9.82% over the forecast period.

Naltrexone And Buprenorphine Market Segmentation

Grand View Research has segmented the global naltrexone and buprenorphine market report based on product, route of administration, application, distribution channel, and region:

Naltrexone And Buprenorphine Product Outlook (Revenue, USD Million, 2021 - 2033)

• Naltrexone

• Buprenorphine

  • BELBUCA

  • Sublocade

  • Suboxone

  • Zubsolv

  • Others

Naltrexone And Buprenorphine Route of Administration Outlook (Revenue, USD Million, 2021 - 2033)

• Naltrexone

  • Oral Administration

  • Injectable Administration

  • Implantable Administration

• Buprenorphine

  • Oral Administration

  • Injectable Administration

  • Implantable Administration

Naltrexone And Buprenorphine Application Outlook (Revenue, USD Million, 2021 - 2033)

• Naltrexone

  • Opioid use disorder (OUD)

  • Alcohol use disorder (AUD

• Buprenorphine

  • Opioid use disorder (OUD)

Naltrexone And Buprenorphine Distribution Channel Outlook (Revenue, USD Million, 2021 - 2033)

• Hospitals Pharmacies

• Retail Pharmacies

• Others

Naltrexone And Buprenorphine Regional Outlook (Revenue, USD Million, 2021 - 2033)

• North America

  • U.S.

  • Canada

  • Mexico

• Europe

  • UK

  • Germany

  • France

  • Italy

  • Spain

  • Denmark

  • Sweden

  • Norway

• Asia Pacific

  • Japan

  • China

  • India

  • Australia

  • South Korea

  • Thailand

• Latin America

  • Brazil

  • Argentina

• Middle East & Africa

  • South Africa

  • Saudi Arabia

  • UAE

  • Kuwait

List of Key Players of Naltrexone And Buprenorphine Market

• Indivior PLC

• Collegium Pharmaceutical (BioDelivery Sciences International, Inc.)

• Alkermes, Inc.

• Orexo US, Inc. (a part of Orexo AB)

• Titan Pharmaceuticals, Inc.

• Omeros Corporations

• Camurus

• Sun Pharmaceutical Industries Ltd