DNA Synthesis Market Size To Reach $8.26 Billion By 2030

DNA Synthesis Market Growth & Trends

The global DNA synthesis market size is expected to reach USD 8.26 billion by 2030, according to a new report by Grand View Research, Inc. The market is expected to register a CAGR of 15.30% from 2024 to 2030 owing to the rising focus on personalized genome sequencing that aids determine patient care. In addition, DNA synthesis has the capability to revolutionize biological research activities for widespread applications in disease monitoring, drug discovery, and pharmacogenomics.  

The COVID-19 pandemic positively impacted the adoption of mRNA-based vaccines for the treatment of COVID-19 infection and different types of cancers. The utility of mRNA boosts the demand for synthetic DNA. Furthermore, a major focus of Covid-19 research is DNA synthesis. Synthetic DNA is used in all PCR analyses. Patients need to use a DNA primer to identify any genomic DNA that may be present in the sample.

Progress in enzyme engineering is boosting the development of different approaches for enzymatic DNA synthesis. It involves the use of enzymes to chain the nucleic acids together in the required sequence and requires further optimization for its widespread applications. Many market players are striving to devise novel technologies for efficient enzymatic production of nucleotides in the lowest turnaround time. For instance, in May 2021, Ribbon Biolabs set a mission of synthesizing DNA sequences of 10,000 base pairs and accomplished a milestone of a 20,000 base pair DNA molecule by December 2021.

Gene synthesis has a broad spectrum of applications in targeted mutagenesis with a specific sequence of nucleotides along with the regulation of a desired phenotypic expression. It forms the primary basis of genetic engineering, which has significantly leveraged the scope and quality of antibodies by the development of antibody fragments with high specificity.

Oligonucleotide synthesis is the laboratory-based production of relatively short fragments of nucleic acids in a required definitive sequence. The technique is an extremely robust practice that facilitates rapid and inexpensive access to the custom-made oligonucleotides of the desired sequence. Companies have devised their oligonucleotide libraries to aid their nucleotide synthesis processes. For instance, in July 2022, Ribbon Biolabs declared that it secured a U.S. Patent that comprises Ribbon Biolabs’ method for the synthesis of a nucleotide molecule using a diverse library of oligonucleotides. The approach comprises a pre-built library of oligonucleotides for efficient access.

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DNA Synthesis Market Report Highlights

• The oligonucleotide synthesis segment dominated the industry in 2023. The larger share of this segment can be attributed to the focus on genomics research, personalized medicine, and understanding the genetic basis of diseases.

• The oligonucleotide synthesis segment dominated the market with the larger revenue share in 2023. The growing awareness and understanding of genetic disorders contribute to the demand for oligonucleotides in diagnostics & potential therapeutic interventions.

• The research and development segment dominated the market with a share of 63.30% in 2023. This is due to the growing use of DNA synthesis to support ongoing research studies across the globe.

• North America dominated the market and accounted for a 39.76% revenue share in 2023. The region experiences market growth due to heightened public awareness, robust medical facilities, and substantial R&D investments. 

DNA Synthesis Market Segmentation

Grand View Research has segmented the global DNA synthesis market on the basis of service type, application, end-use, and region:

DNA Synthesis Service Type Outlook (Revenue, USD Million, 2018 - 2030)

• Oligonucleotide Synthesis

• Standard Oligonucleotide Synthesis

• Custom Oligonucleotide Synthesis

• Gene Synthesis

• Custom Gene Synthesis

• Gene Library Synthesis

DNA Synthesis Length Outlook (Revenue, USD Million, 2018 - 2030)

• Oligonucleotide Synthesis

  • Less than 50 nt

  • 51-100 nt

  • 101-150 nt

  • More than 150 nt

• Gene Synthesis

  • Less than 500 nt

  • 501-1000 nt

  • 1001-1500 nt

  • 1501-2000 nt

  • 2001-2500 nt

  • More than 2500 nt

DNA Synthesis Application Outlook (Revenue, USD Million, 2018 - 2030)

• Research and Development

  • Oligonucleotide Synthesis

    • PCR

    • NGS

    • CRISPR

    • Cloning and Mutagenesis

    • Others

  • Gene Synthesis

    • Synthetic Biology

    • Vaccine Development

    • Genetic Engineering

    • Others

• Diagnostics

• Therapeutics

  • RNAi Therapies

  • Antisense Oligonucleotide-based Therapies

  • Others

DNA Synthesis End-use Outlook (Revenue, USD Million, 2018 - 2030)

• Biopharmaceutical and Diagnostics Companies

• Academic and Research Institutes

• Contract Research Organizations

DNA Synthesis Regional Outlook (Revenue, USD Million, 2018 - 2030)

• North America

  • U.S.

  • Canada

• Europe

  • Germany

  • UK

  • France

  • Italy

  • Spain

  • Denmark

  • Sweden

  • Norway

• Asia Pacific

  • China

  • Japan

  • India

  • South Korea

  • Australia

  • Thailand

• Latin America

  • Brazil

  • Mexico

  • Argentina

• MEA

  • South Africa

  • Saudi Arabia

  • UAE

  • Kuwait 

List of Key Players in DNA Synthesis Market

• Thermo Fisher Scientific, Inc

• Twist Bioscience

• BIONEER CORPORATION

• Eton Bioscience, Inc.

• LGC Biosearch Technologies

• IBA Lifesciences GmbH

• Eurofins Scientific

• Integrated DNA Technologies, Inc.

• Quintara Biosciences

• GenScript