Vitamin K2 Market Size, Share & Trends Analysis Report By Product (MK-4, MK-7), By Dosage Form, By Source, By Indication, By Application, By Distribution Channel, By Region, And Segment Forecasts, 2024 - 2030

Vitamin K2 Market Size & Trends

The global vitamin K2 market size was estimated at USD 421.1 million in 2023 and is projected to grow at a CAGR of 10.8% from 2024 to 2030. Increasing consumer awareness of its health benefits, demographic factors such as an aging population, changing dietary preferences towards functional foods, and ongoing research validating its therapeutic properties are driving factors which is attributed to the growth of the vitamin K2 market.

Vitamin K2 is recognized for its positive effects on bone health, cardiovascular health, and overall well-being. As people become more focused on maintaining good health and preventing chronic diseases, the demand for vitamin K2 supplements is expected to increase.In April 2023, Petrovax Pharm, a leading force in Russia's biotech sector renowned for its innovative immunobiological products and vaccines, introduced SunDevit to the Russian market. This cutting-edge complex, distinguished by its unique combination of vitamins D3 and K2, was specifically designed to enhance the immune system and support the health of muscles, bones, and joints.

The rising rates of osteoporosis and cardiovascular diseases globally are significantly boosting the demand for vitamin K2 products. Vitamin K2 is vital for bone health, as it helps direct calcium to strengthen bones and reduce fracture risks. Additionally, research indicates that vitamin K2 can prevent arterial calcification and lower the risk of heart issues. With an aging population and increasing cases of these conditions, interest in vitamin K2 supplements is growing. According to a study in published In February 2024, highlighted that Vitamin K2 notably reduces weight, abdominal fat, and liver fat in mice on a high-fat diet, marking a significant step in understanding its protective role against non-alcoholic fatty liver disease (NAFLD).

The growth of the vitamin K2 market is further driven by key players expanding their product offerings. Companies are focusing on creating innovative formulations and delivery methods to meet diverse consumer preferences and improve product effectiveness. This includes new forms like capsules, tablets, soft gels, and liquids, as well as combining vitamin K2 with other supplements for specific health benefits. The diversifying their product lines, is anticipated to propel the demand for vitamin K2 in the nutraceutical industry. In January 2021, MENADIONA launched a new Vitamin K2 MK-7 grade for nutraceutical use, adhering to US Pharmacopeia standards for purity. This expansion into Vitamin K2 MK-7 complements their existing Vitamin K2 MK-4 offerings, emphasizing their expertise in Vitamin K chemistry and aiming to broaden their market presence.

Furthermore, government agencies worldwide are increasingly recognizing the importance of promoting preventive healthcare through nutrition and dietary supplements. This has led to favorable regulatory frameworks that encourage innovation and quality assurance in the production of vitamin K2 supplements. Thus, the regulatory support for functional food ingredients like vitamin K2, coupled with ongoing research advancements validating its health benefits, are further propelling the growth of the market. Additionally, scientific studies continue to uncover new therapeutic applications of vitamin K2 beyond bone and heart health, creating opportunities for market expansion. For instance, in October 2023, a study featured in Food & Function revealed that vitamin K supplements significantly regulate Fasting Blood Sugar (FBS) and Insulin Resistance (HOMA-IR) and lower the risk of Type 2 Diabetes Mellitus (T2DM).

Product Insights

The MK-4 segment held the largest market share in 2023. This is attributed to the high demand of MK-4 as a synthetic form of menaquinone-4. MK4 is known to enhance bone health and prevent osteoporosis by improving bone mineral density and reducing fracture risk. It is further anticipated to benefit cardiovascular health by lowering the risk of arterial calcification. Increasing consumer interest in MK4 supplements for these health benefits is driving its demand.In October 2023, Smidge announced a new launch: grass-fed, Australian Emu Oil capsules, a premium source of real food vitamin K2 in the MK-4 form. These softgels, sourced from Heritage-bred emus, offer a blend of natural nutrients crucial for a holistic diet, including vitamin K2 (MK-4) and omega fatty acids.

The MK-7 segment is expected to grow at the fastest rate during the forecast period. This growth is due to MK-7's natural form, menaquinone-7, which is derived from fermented foods like natto. MK-7 is preferred for its superior bioavailability and longer-lasting effects compared to MK-4. Studies have shown that MK-7 supports cardiovascular health by preventing arterial calcification and aiding healthy blood clotting. For instance, in February 2024, it was reported that Kappa Bioscience's Vitamin K2 MK-7 at a daily dose of 375 µg may help reduce heart disease risk by slowing arterial stiffness in diabetic chronic hemodialysis patients over a 24-week period. Moreover, the rise in vegan and plant-based diets has increased demand for MK-7 supplements, which are often sourced from non-animal origins. Growing consumer awareness about the benefits of different forms of vitamin K2 has boosted demand for MK-7 products, with market data showing increased sales due to its role in maintaining health. These factors are anticipated to impel the growth of the segment over the forecast period.

Dosage Form Insights

In 2023, capsules/tablets dominated the market with a leading market share of 41.6%. This is attributed to the easy production, strong stability, and precise dosage control. These forms are extensively used in pharmaceuticals and nutraceuticals because they shield active ingredients from oxidation, light, and moisture, extending shelf life. Moreover, their solid format facilitates convenient storage and transportation.In December 2022, J-Oil Mills secured trademarks for Menatto, a vitamin K2 MK-7 ingredient, across the U.S., Japan, Europe, and Australia. Manufactured in a certified Japanese facility, Menatto is approved for use in a range of products including food, beverages, and dietary supplements, available in tablets, capsules, oil and powder formats.

The softgels segment is expected to grow rapidly over the forecast period. This growth is driven by their excellent absorption rate and convenience for users. Softgels are typically made from gelatin or other materials and contain liquid forms of active ingredients, which are easier for the body to absorb. This form is particularly advantageous for people who find it challenging to swallow pills or capsules. For instance, Smidge offers softgels sourced from Heritage-bred emus, providing a natural blend of essential nutrients like vitamin K2 (MK-4) and omega fatty acids, supporting a well-rounded diet.

Source Insights

In 2023, synthetic vitamin K2 dominated the market with largest market share. This is attributed to the cost-effectiveness and scalability. Synthetic vitamin K2 is manufactured at a lower cost compared to natural extraction methods, making it a cost-effective option for producers. Moreover, it allows for standardized potency and purity, ensuring consistent product quality. Many supplement manufacturers choose synthetic vitamin K2 for these benefits, especially in formulations where cost and precise dosages are critical factors. For instance, Life Extension provides Bone Restore Elite with Super Potent K2 to reduce the risk of age-related bone density loss, which particularly effects post-menopausal women.

The natural segment is expected to grow at the fastest CAGR over the forecast period. This is attributed to the increasing consumer preference for natural and organic products, including those containing natural sources of vitamin K2. In addition, there is a growing demand for vitamin K2 derived from natto, a traditional Japanese food, as consumers perceive natural products to be healthier and more environmentally friendly. In October 2023, MD Logic Health introduced a new Natural Vitamin D3 + K2 supplement, combining naturally sourced vitamin D3 with both MK-4 and MK-7 forms of vitamin K2. This product aims to support bone, dental, and cardiovascular health by harnessing the synergistic benefits of vitamins D3 and K2.

Indication Insights

The bone health segment held the largest market share of 36.2% in 2023. Vitamin K2 is crucial for bone health, regulating calcium metabolism and aiding in calcium deposition into bones. Recognized for improving bone density and reducing osteoporosis risk, it is particularly beneficial in enhancing bone mineral density and lowering fracture risks in postmenopausal women. The aging global population and increasing incidents of bone disorders have boosted the demand for vitamin K2 supplements. Intake of supplements, including calcium and vitamin D, often features vitamin K2 to support overall bone health. In July 2021, Disproquima introduced a soy-based, sustainable vitamin K2, needed for improving bone health. The company emphasizes that higher levels of MK-7 in the body are directly linked to improved bone density. These factors are anticipated to impel the growth of the segment over the forecast period.

The heart health segment is projected to grow at the fastest rate from 2024 to 2030. Vitamin K2 is essential for heart health as it prevents artery calcification and reduces the risk of cardiovascular disease. Studies indicate that vitamin K2 activates proteins that inhibit calcium buildup in arteries, which lowers arterial stiffness and the likelihood of cardiovascular events. There is increasing consumer interest in diets and supplements promoting heart health, including those containing vitamin K2. Healthcare providers endorse vitamin K2 supplements for preventing cardiovascular diseases.In November 2022, Conagen announced the development of new vitamin K2 forms through its fermentation platform, focused on enhancing heart health. The product is anticipated to improve cardiovascular health significantly. Thus, these are expected to propel the growth foreseeable.

Application Insights

In 2023, the health supplements segment led the market in revenue with a dominant share and it is projected to grow at the fastest rate over the forecast period. This growth is fueled by rising consumer awareness of the importance of maintaining optimal health and wellness, increasing health consciousness, and the demand for nutritional products. Globally, higher disposable incomes have driven the popularity of premium health supplements, including those containing vitamin K2. In July 2022, the Industry Transparency Center's survey of 3,500 dietary supplement consumers revealed that 63% actively manage their health, 76% use dietary supplements, and 62% have used Vitamin K2, ranking it in the top 10 ingredients.

The functional foods & beverages segment is set to grow significantly due to increased consumer awareness of vitamin K2's health benefits. This is supported by rising osteoporosis and cardiovascular disease rates, coupled with an aging population. Furthermore, technological advances in food production have facilitated the addition of vitamin K2 to various products like dairy, beverages, and supplements, driving the launch of new fortified items. In addition, according to a study conducted by the University of Copenhagen in October 2022, published in the 'International Journal of Nephrology and Renovascular Disease' demonstrated that daily MK-7 supplements for six weeks effectively raised vitamin K levels in chronic kidney disease patients at risk of deficiency, outperforming a vitamin-rich diet in reducing deficiency indicators.

Distribution Channel Insights

The offline segment held the largest market share in 2023. Brick-and-mortar stores like pharmacies, health food stores, and supermarkets outlets provide immediate purchase convenience and allow consumers to assess product quality directly.These outlets provided a significant advantage in terms of consumer trust, accessibility, and immediate product availability. These factors are anticipated to propel the demand for offline stores across the world and thereby impelling the growth of the segment over the forecast period.

The online segment is expected to witness a fastest CAGR over the forecast period. This is attributed to the convenience, accessibility, competitive pricing, and the ability to shop anytime and anywhere. Moreover, online shopping offers benefits such as home delivery, a broader range of brands and products compared to physical stores, and the ability to compare prices and read customer reviews. The shift towards buying health supplements like vitamin K2 online is driven by higher internet usage, busy lifestyles, and the ease of researching products before making a purchase. Thus, impelling the growth of the segment over the forecast period.

Regional Insights

North America's vitamin K2 marketis expected to grow significantly, owing to the increasing awareness of bone and heart health benefits, a preference for natural products, and FDA approval. Economic factors like rising middle-class and healthcare spending, combined with the popularity of vegan and vegetarian diets, are boosting demand for plant-based K2. Technological advancements in production are also enhancing K2 product quality and availability. In March 2022, LT Health Solutions, Inc. announced plans to distribute J-Oil Mills' menatto Vitamin K2 (MK-7) across North America, for cardiovascular, bone, and overall health benefits. Thereby boosting the demand for vitamin K2 over the forecast period.

U.S. Vitamin K2 Market Trends

Vitamin K2 market in the U.S. is projected to expand over the period, owing to the growing consumer awareness of its benefits for bone and heart health. The market is shaped by an aging population focusing on preventive health measures. FDA approvals of health claims related to vitamin K2 further stimulate demand. Advances in production technology have also contributed to market growth. Sales of vitamin K2 supplements are on the rise across different sales channels. In October 2022, Kappa Bioscience launched the first USDA organic-certified vitamin K2-MK7 under the K2Vital brand. This bioactive form is tailored for oil-based supplements, allowing manufacturers to create better quality organic health products and enter the growing organic market segment. These factors are anticipated to boost the market growth of vitamin K2 in the U.S.

Europe Vitamin K2 Market Trends

Europe's vitamin K2 market is recognized as a lucrative region owing to the rising interest in preventive healthcare and a growing preference for natural and organic products. The aging population's demand for bone health support is driving growth in the vitamin K2 supplement market. Additionally, strict regulations on health claims and product quality are influencing consumers to choose high-quality vitamin K2 products. In February 2024, ILSI Europe launched a new Vitamin K2 Task Force composed of industry experts and academics to promote awareness and deepen scientific understanding of Vitamin K2's health. This is expected to boost the growth of the market over the forecast period.

Asia Pacific Vitamin K2 Market Trends

The Asia Pacific vitamin K2 market holds a leading 36.3% market share and is expected to grow rapidly from 2024 to 2030. Growth in the region is driven by a rising middle-class population with greater disposable incomes and increasing awareness of nutritional supplements for overall health. Countries like Japan and South Korea, known for their focus on traditional medicine, show significant adoption of vitamin K2 products. Advances in manufacturing technology are making these supplements accessible to consumers across various income levels. In December 2023, South Korea's Ministry of Food and Drug Safety (MFDS) proposed approving vitamin K2 as a health functional food ingredient, responding to industry requests and recognizing its global use in health supplements. Minister Oh Yu-Kyoung's visit to local vitamin K2 manufacturer GF-Fermentech highlights the ministry's proactive role in evaluating this ingredient. Similarly, in June 2022, Fermenta Biotech and Kappa Bioscience, a Norwegian company, partnered to distribute K2VITAL Vitamin K2 MK-7 in India. This collaboration combines Kappa's manufacturing and Fermenta's distribution expertise, enhancing the supply of Vitamin K2, which supports calcium transport and works well with vitamin D3. These factors are anticipated to propel the demand for vitamin K2 over the forecast period.

Key Vitamin K2 Company Insights

Key players operating in the vitamin K2 market are undertaking various initiatives to strengthen their market presence and increase the reach of their products and services. Strategies such as expansion activities and partnerships are playing a key role in propelling the market growth.

Recent Developments

• In March 2024, SunWay Biotech and Gnosis by Lesaffre launched MenaQ7 Metabolic, a blend of vitamin K2 and a statin-free red yeast rice fermentate, Ankascin 568-R, designed to support heart and bone health. This new ingredient, which is free of Monacolin K and has achieved NDI status, is backed by over 130 scientific studies on its metabolic benefits.

• In April 2023, Kappa Bioscience, renowned for producing vitamin K2 through its flagship brand K2VITAL, plans to demonstrate for the first time the combined benefits of its all-trans vitamin K2 MK-7 ingredients alongside the comprehensive offerings of the Balchem Human Nutrition & Health (HN&H) portfolio at Vitafoods Europe.

• In June 2022, Balchem Corp. announced their agreement to acquire Kappa Bioscience, a market-leading producer of vitamin K2. This strategic deal aligns with Balchem's vision of promoting health and wellness. Kappa Bioscience is committed to developing high-quality health solutions centered around vitamin K2 to enhance people's quality of life.

Vitamin K2 Market Report Scope

Global Vitamin K2 Market Report Segmentation

This report forecasts revenue growth at global, regional, and country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2018 to 2030. For this study, Grand View Research has segmented the global vitamin K2 market report based on product, dosage form, indication, application, distribution channel, and region.

• Product Outlook (Revenue, USD Million, 2018 - 2030)

  • MK-7

  • MK-4

• Dosage Form Outlook (Revenue, USD Million, 2018 - 2030)

  • Capsules/Tablets

  • Softgels

  • Liquid

  • Others

• Source Outlook (Revenue, USD Million, 2018 - 2030)

  • Natural

  • Synthetic

• Indication Outlook (Revenue, USD Million, 2018 - 2030)

  • Bone Health

  • Heart Health

  • Blood Clotting

  • Others

• Application Outlook (Revenue, USD Million, 2018 - 2030)

  • Health Supplements

  • Functional Foods and Beverages

• Distribution Channel Outlook (Revenue, USD Million, 2018 - 2030)

  • Offline

    • Pharmacies & Drug Stores

    • Hypermarkets/Supermarkets

    • Others

  • Online

• Regional Outlook (Revenue, USD Million, 2018 - 2030)

  • North America

    • U.S.

    • Canada

    • Mexico

  • Europe

  • Germany

  • UK

  • France

  • Italy

  • Spain

  • Denmark

  • Sweden

  • Norway

  • Asia Pacific

    • China

    • Japan

    • India

    • South Korea

    • Australia

    • Thailand

  • Latin America

    • Brazil

    • Argentina

  • MEA

    • South Africa

    • Saudi Arabia

    • UAE

    • Kuwait