Single-use Bioprocessing Connectors Market Size, Share & Trends Analysis Report By Product (Aseptic Connectors, Conventional Connectors), By Application (Upstream Bioprocessing, Downstream Bioprocessing), By End Use, By Region, And Segment Forecasts, 2025 - 2030

Market Size & Trends

The global single-use bioprocessing connectors market size was estimated at USD 1.26 billion in 2024 and is expected to grow at a CAGR of 15.77% from 2025 to 2030. The expansion of the market can be linked to several important factors. These include the growing use of single-use bioprocessing systems, an increase in the production of biologics and biosimilars, and advancements in the design of connectors.

The evolution of single-use bioprocessing connectors has been driven by advancements in design, materials, and automation, enhancing sterility, efficiency, and scalability in biopharmaceutical manufacturing. Advanced aseptic connectors feature double sterile barriers, integrated seals, and self-closing mechanisms to prevent contamination. The advanced products also feature genderless designs that eliminate the need for male/female configurations, simplifying assembly and reducing human error. For instance, in April 2023, CPC announced the launch of its AseptiQuik W Series aseptic connectors. These connectors are notable for being the industry's largest genderless aseptic connectors, featuring a 1-1/2-inch flow path that facilitates the transfer of hundreds of liters per minute. This advancement is aimed at significantly reducing fluid transfer times in bioprocesses.

Moreover, the growing biopharmaceutical industry is a major driver for the single-use bioprocessing connectors market, as manufacturers increasingly adopt flexible, aseptic, and scalable bioprocessing solutions. In 2024, a total of 50 new therapeutics were approved by the FDA, which included 10 monoclonal antibodies and 3 bispecific antibodies among the protein-based drugs, making up 32% of the approvals. Additionally, there were 2 protein-based drugs and 2 small nucleic acid drugs, accounting for 4% of the total approvals. The rise of monoclonal antibodies (mAbs), and advanced therapies has accelerated the need for SUS, including connectors for aseptic fluid transfer and contamination-free processing. For instance, Lynx CDR connectors, offered by Merck KGaA, are specifically designed for bulk fluid transfer in large-scale mAb production.

The COVID-19 pandemic significantly accelerated the adoption of single-use bioprocessing technologies, including single-use connectors, due to the urgent demand for vaccine production, biopharmaceutical manufacturing, and rapid scale-up of biologics production. Single-use systems provide the flexibility to rapidly scale up production without the need for extensive cleaning and validation, which is essential for multi-product facilities. Manufacturers such as Thermo Fisher, Sartorius, Danaher, and Merck invested in new production plants to expand manufacturing facilities to meet rising demand. Several single-use bioprocessing connectors were used in vaccine research and manufacturing, including AseptiQuik Connectors offered by CPC, and Sterile ReadyMate Connectors offered by Cytiva, among several others.

Market Concentration & Characteristics

The single-use bioprocessing connectors market has seen moderate to high innovation, driven by the growing adoption of flexible biomanufacturing, sterility requirements, and automation advancements. Innovation is focused on enhancing aseptic processing, improving material compatibility, integrating smart technologies, and ensuring regulatory compliance. Key areas of innovation include genderless and self-sealing connectors, automated sterile connectors, and pre-sterilized and ready-to-use connectors.

The single-use bioprocessing connectors industry has witnessed a high level of collaboration and partnership activities, driven by the need for scalability, regulatory compliance, and supply chain resilience. These collaborations involve biopharma companies, contract manufacturers, raw material suppliers, and technology providers to advance innovation and address market demands. For instance, in November 2021, Avantor acquired Masterflex to integrate fluid handling solutions, including single-use connectors.

Regulations play a critical role in shaping the single-use bioprocessing connectors industry, influencing product design, material selection, sterility assurance, and market adoption. Regulatory bodies such as the FDA (U.S.), EMA (Europe), USP, ISO, and WHO set stringent guidelines to ensure the safety, quality, and performance of Single-use Bioprocessing Connectors used in biopharmaceutical manufacturing.

The single-use bioprocessing connectors market is experiencing significant product expansion, driven by advancements in aseptic processing, modular biomanufacturing, and automation. Companies are expanding their product portfolios to cater to increasing biopharmaceutical production needs, including cell & gene therapies, monoclonal antibodies (mAbs), vaccines, and biosimilars.

The single-use bioprocessing connectors market is experiencing strong regional expansion, driven by increasing biopharmaceutical production, investments in advanced therapies, and regulatory support. While North America and Europe dominate the market, Asia-Pacific (APAC) is witnessing the fastest growth, and Latin America, the Middle East, and Africa (MEA) are emerging markets.

Product Insights

The aseptic connectors segment held the largest market share of 65.7% in 2024. Aseptic connectors are essential components used in fluid transfer, filtration, mixing, and storage in biopharmaceutical and vaccine production. They enable secure, contamination-free connections in single-use systems, reducing cross-contamination risks and improving process efficiency.

Conventional connectors are expected to grow at a significant CAGR during the forecast period. This is attributed to their cost-effectiveness compared to aseptic connectors. Conventional connectors are basic single-use connectors that facilitate fluid transfer but may not provide full aseptic assurance. They are used in less contamination-sensitive applications such as Buffer & media preparation where sterility is not a major concern.

Application Insights

In 2024, the upstream bioprocessing segment held the largest market share of 45.7%. Upstream bioprocessing involves the initial stages of biological drug production, including cell culture, fermentation, and media preparation. Single-use connectors play a critical role in ensuring sterile, contamination-free fluid transfer during these processes.

The downstream processing segment is expected to grow at the fastest CAGR during the forecast period. The market is growing for this segment due to several key drivers such as increasing focus on aseptic processing and sterility assurance, and cost and time efficiency advantages over stainless steel assemblies. Biopharmaceutical manufacturing involves purification, filtration, and final drug formulation, where single-use connectors play a critical role in sterile, contamination-free fluid transfer.

End Use Insights

The biopharmaceutical & pharmaceutical companies segment held the largest market share of 44.0% in 2024. Growing demand for cell & gene therapies and personalized medicine is increasing the adoption of single-use bioprocessing connectors in upstream & downstream processing by these end-users. For instance, December 2021, Pfizer Inc. announced the opening of a new advanced clinical manufacturing facility in Durham, North Carolina. This facility enhances Pfizer's comprehensive capabilities in gene therapy and builds upon its existing presence in the state. The Durham facility is part of an $800 million investment made to establish three scalable gene therapy manufacturing facilities, supporting Pfizer’s ongoing commitment to gene therapy research, development, and production using single-use technology.

On the other hand, the CMOs & CROs segment is anticipated to register the fastest CAGR over the forecast period. The rising trend of outsourcing services to Contract Research Organizations (CROs) and Contract Manufacturing Organizations (CMOs) has greatly contributed to the expansion of this end-user segment within the single-use bioprocessing connectors market. As biologics and cell and gene therapies continue to evolve and gain importance in the healthcare sector, biopharmaceutical companies are increasingly looking for cutting-edge technologies to enhance the efficiency of their production processes.

Regional Insights

North America single-use bioprocessing connectors market dominated the global industry with a share of 48.3% in 2024. This significant market share can be attributed to the expansion of the biotechnology and pharmaceutical sectors, advancements in product offerings, and the rising prevalence of diseases like cancer. Additionally, increased investments and funding in drug discovery research play a crucial role. For instance, in May 2022, Cytiva opened a new manufacturing facility in Switzerland. The facility focuses on manufacturing single-use kits and consumables.

U.S. Single-use Bioprocessing Connectors Market Trends

The substantial share of the U.S. single-use bioprocessing connectors market can be attributed mainly to the presence of large-scale manufacturing facilities for biopharmaceuticals. The biopharmaceutical sector is considered the most R&D-intensive in the U.S., and its development is recognized as a high-impact factor in the industry.

Europe Single-use Bioprocessing Connectors Market Trends

Europe's single-use bioprocessing connectors industry was identified as a lucrative region in this industry. European countries, such as the UK, France, Italy, Germany, Switzerland, Spain, and the Netherlands, hold a significant position in the biopharmaceutical sector. Several events and summits addressing innovations in the field of bioprocessing are conducted in the region

The UK single-use bioprocessing connectors market is growing rapidly, driven by government investments to assist local players and create a competitive advantage against international players.

The Single-use Bioprocessing Connectors market in Germany is experiencing significant growth. The presence of key players for single-use technology in Germany and contract service providers continuing to invest in the expansion of their single-use capacity are among the factors driving the country’s market.

Asia Pacific Single-use Bioprocessing Connectors Market Trends

Asia Pacific is anticipated to showcase the fastest CAGR of 16.8% during 2025-2030. The fast-paced growth of this region is expected to be mainly driven by China and India. Key factors driving the industry growth include an increase in access to technologies, a large patient pool, and improvement in healthcare infrastructure. The increasing adoption of single-use assemblies in emerging markets by mature players to refine processes is also a significant factor driving the region’s growth. Moreover, the growing biotechnology sector, the presence of a large number of research & academic institutes, and significant investments by market participants are projected to drive the region’s market.

China’s Single-use Bioprocessing Connectors market is rapidly expanding due to the higher demand for biopharmaceuticals. Several international companies have expanded their manufacturing footprint in this region by forming mutually beneficial partnerships with China-based entities.

Japan’s Single-use Bioprocessing Connectors market is experiencing significant growth, driven by the significant involvement of government bodies in the active promotion of biotechnology and related industries.

MEA Single-use Bioprocessing Connectors Market Trends

The MEA single-use bioprocessing connectors market is expected to witness a moderate growth forecast period owing to heterogeneity in countries' economic progress. Furthermore, pharmaceutical, biotechnology, healthcare, and other related life science sectors require a skilled workforce and high investment in R&D. Lack of skilled personnel is limiting market growth in this region.

The Single-use Bioprocessing Connectors market in South Africa has witnessed subdued growth over the past few years. However, South Africa has the largest life sciences and healthcare markets in the MEA, and global companies such as Adcock Ingram and Aspen Pharmacare have originated in this country.

UAE Single-use Bioprocessing Connectors market is experiencing strong growth, fueled by the ongoing developments in the healthcare system.

Key Single-use Bioprocessing Connectors Company Insights:

The market players operating in the single-use bioprocessing connectors market are adopting product approval to increase the reach of their products in the market, improve their availability in diverse geographical areas, and expand to enhance production/research activities. This strategy enables companies to increase their capabilities, expand their product portfolios, and improve their competencies.

Recent Development

• In January 2025, CPC (Colder Products Company), a subsidiary of Dover Corporation, launched its MicroCNX Nano Series aseptic connectors. These connectors are designed to enhance the efficiency of closed sterile processing in cell and gene therapy. This innovation addresses the industry's reliance on outdated techniques, such as tube welding and biosafety cabinets, which can be cumbersome and time-consuming.

• In October 2024, Thermo Fisher Scientific announced the establishment of a Bioprocess Design Centre in Genome Valley, Hyderabad, in collaboration with the Government of Telangana. This facility will cover 10,000 square feet and is expected to commence operations in early 2025. Such developments are expected to grow demand for the Single-use Bioprocessing Connectors for bioprocessing applications.

• In September 2024, CPC announced the launch of its new MicroCNX ULT Series, an aseptic micro-connector designed specifically for cell and gene therapy cryopreservation.

Single-use Bioprocessing Connectors Market Report Scope

Global Single-use Bioprocessing Connectors Market Report Segmentation

This report forecasts revenue growth and analyzes the latest trends in each of the sub-segments from 2018 to 2030. For this study, Grand View Research has segmented the global market based on product, application, end use, and region.

• Product Outlook (Revenue, USD Million, 2018 - 2030)

  • Aseptic Connectors

  • Conventional Connectors

• Application Outlook (Revenue, USD Million, 2018 - 2030)

  • Upstream Bioprocessing

  • Downstream Bioprocessing

  • Fill-finish Operations

• End Use Outlook (Revenue, USD Million, 2018 - 2030)

  • Biopharmaceutical & Pharmaceutical Companies

  • CROs & CMOs

  • Academic & Research Institutes

• Regional Outlook (Revenue, USD Million, 2018 - 2030)

  • North America

    • U.S.

    • Canada

    • Mexico

  • Europe

    • Germany

    • UK

    • France

    • Italy

    • Spain

    • Denmark

    • Sweden

    • Norway

  • Asia Pacific

    • China

    • India

    • Japan

    • South Korea

    • Australia

    • Thailand

    • South Korea

  • Latin America

    • Brazil

    • Argentina

  • Middle East and Africa (MEA)

    • South Africa

    • Saudi Arabia

    • UAE

    • Kuwait