Plasmid Purification Market Size, Share & Trends Analysis Report By Product & Service (Kits & Reagents, Instruments), By Grade (Molecular Grade, Transfection Grade), By Application, By End-use, By Region, And Segment Forecasts, 2024 - 2030

Plasmid Purification Market Size & Trends

The global plasmid purification market size was estimated at USD 1.72 billion in 2023 and is projected to grow at a CAGR of 11.60% from 2024 to 2030. The growing demand for recombinant DNA technology products and technological advancements in plasmid purification are some of the factors driving market growth. Moreover, the rising acceptance of cell and gene therapy to treat chronic diseases further propels market growth.

Plasmids serve as vectors for cloning DNA fragments, enabling researchers to create multiple copies of specific genes or sequences. Protein engineering relies heavily on cloning and mutagenesis techniques, which are fundamental for modifying protein sequences to create therapeutic proteins. Thus, the increasing emphasis on protein engineering for drug development drives the market.

The increasing research & development in the biopharmaceutical and biologics industry for novel products, including vaccines and gene therapies, has elevated the need for high-quality plasmid DNA. As more companies invest in biologics, the demand for efficient plasmid purification processes increases. Continuous innovations in biotechnology enhance the methods used for plasmid extraction and purification. New technologies, such as automated systems and improved chromatography techniques, make purification processes faster and more efficient.

Recombinant proteins are artificially engineered proteins created by combining genetic material through biotechnological techniques, such as molecular cloning and gene editing, using plasmids. Furthermore, there is a growing commercial demand for molecular cloned products and recombinant proteins across various industries, including pharmaceuticals, biotechnology, and academia. In agriculture, recombinant proteins are used to develop genetically modified crops with enhanced traits and improved nutritional content.

In addition, the increasing emphasis on personalized medicine and genetic research further propels the demand for plasmid purification products. As the field of genomics advances, there is a growing need for high-quality plasmid DNA for applications in gene expression profiling and CRISPR technology. Efficient purification of plasmids is essential for the success of these applications, as the quality of the starting material directly impacts downstream results.

The COVID-19 pandemic significantly impacted the DNA and gene cloning services market. The pandemic led to disruptions in supply chains, temporary closures of research facilities, and a shift in priorities toward combating the virus. However, the pandemic highlighted the importance of advanced genetic technologies in understanding and combating infectious diseases. The rapid development of vaccines using mRNA technology showcased the potential of genetic engineering in responding to public health emergencies.

Market Concentration & Characteristics

The market is experiencing a significant degree of innovation driven by advancements in genetic engineering and cloning technologies and the increasing demand for personalized medicine and gene therapies. The market is witnessing a surge in the adoption of novel and advanced DNA & gene cloning technologies, propelling growth and creating new opportunities for companies offering gene synthesis, custom cloning, sub-cloning, and other related services.

The industry is experiencing a moderate level of merger and acquisition activities undertaken by several key players. This is due to several factors, including the desire to gain a competitive advantage in the industry and the need to consolidate in a rapidly growing market. However, market players are engaged in collaboration and partnerships to expand their product & service portfolios owing to the rapid advancements in molecular & recombinant DNA technologies.

rDNA technology raises ethical concerns related to genetic manipulation, potential misuse of technology, and implications for biodiversity. Regulatory bodies often impose guidelines to ensure the responsible use of gene cloning techniques and to address ethical dilemmas associated with altering genetic material.

Key players are adopting the strategy of increasing production capacity and expanding their market reach to improve the availability of their products and services in diverse geographic areas. In addition, companies are launching new platforms to strengthen their product and service portfolios. For instance, in August 2023, CD Bioparticles launched a new line of DNA extraction and purification kits. The kits are designed for reliable and rapid isolation and purification of DNA, including plasmid DNA, genomic DNA, cell-free DNA (cfDNA), mitochondrial DNA, tissue DNA, and PCR products.

The industry is witnessing moderate regional expansion, driven by an increasing customer base for cloned products. The expansion of biotechnology sectors in emerging markets is creating new opportunities for plasmid purification services and products. Countries with developing healthcare infrastructures are increasingly investing in biotechnological advancements. Furthermore, as scientific awareness of cell and gene therapy continues to grow globally and access to biotechnological tools improves in emerging markets, major market players are expected to enhance their regional expansion efforts.

Product & Service Insights

The products segment dominated the market with the largest revenue share of 72.93% in 2023. This growth is attributed to the advancements in instruments and kits designed for efficient and reliable purification processes. Instruments such as automated purification systems have gained popularity due to their ability to streamline workflows, reduce manual errors, and increase throughput. In addition to instruments, the kits and reagents segment plays a crucial role in the market growth. Companies like Takara Bio and MP Biomedicals offer a range of kits that cater to different scales of purification, from mini-preps to large-scale preparations.

The services segment is expected to grow at the fastest CAGR of 12.58% from 2024 to 2030. The demand for high-quality plasmid DNA is increasing in academic and industrial laboratories for applications such as gene therapy, vaccine development, and synthetic biology. Companies specializing in plasmid purification offer tailored services that cater to specific research needs, ensuring the delivery of high-purity plasmids essential for downstream applications. This demand is fueled by the growing emphasis on personalized medicine, where plasmid DNA is crucial in developing targeted therapies tailored to individual genetic profiles.

Grade Insights

Based on grade, the molecular-grade segment led the market with the largest revenue share of 58.42% in 2023, driven by the demand for high-quality plasmid DNA in various applications. Molecular-grade plasmid DNA is essential for applications such as gene therapy, vaccine development, and synthetic biology. In addition, the rise of personalized medicine has significantly impacted the demand for molecular-grade plasmid purity. Moreover, advancements in molecular-grade plasmid purification technologies are propelled by the increasing complexity of therapeutic modalities, such as CAR-T cell therapies and mRNA vaccines.

The transfection grade segment is expected to grow at the fastest CAGR of 13.24% over the forecast period. Transfection-grade plasmids are characterized by their high purity and yield, which are essential for successful transfection into mammalian cells. The demand for high-quality plasmid DNA has surged due to the increasing prevalence of genetic engineering techniques and the growing interest in personalized medicine. As the market continues to evolve, the growing focus on high-quality purification technologies is likely to drive innovation and investment. Transfection-grade plasmid purification is becoming crucial for the advancement of genetic research and therapeutic development.

End-use Insights

Based on end use, the academic and research institutes segment led the market with the largest revenue share of 40.12% in 2023. These institutes rely on high-quality plasmid DNA for various applications, including transfection and gene editing. Researchers utilize plasmids as vectors to deliver genes into cells, facilitating studies on gene function and the development of gene therapies. The ability to produce and purify plasmid DNA with high yield and purity is essential for achieving reproducible experiment results. Moreover, the rise of CRISPR and other gene editing technologies has further amplified the need for reliable plasmid purification solutions. In addition, the market for plasmid purification is expected to evolve as academic and research institutes increase their emphasis on synthetic biology and personalized medicine. The integration of automation and high-throughput purification systems is anticipated to simplify workflows and enhance efficiency in plasmid production.

The contract research organizations (CROs) segment is projected to grow at the fastest CAGR from 2024 to 2030. CROs facilitate preclinical and clinical studies and require efficient purification methods to ensure the plasmids used are free from contaminants. The efficiency of gene editing heavily depends on the quality of the plasmid DNA, making robust purification processes essential. CROs are increasingly adopting automated purification systems that streamline workflows, reduce turnaround times, and maintain high-quality control standards. Moreover, CROs are expected to expand their capabilities to include next-generation plasmid purification methods that address the challenges associated with high-throughput applications.

Application Insights

Based on application, the cloning and protein expression segment led the market with the largest revenue share of 48.76% in 2023. The increasing demand for recombinant proteins in therapeutic applications, diagnostics, pharmaceutical & agricultural sectors, and research has propelled advancements in plasmid purification technologies. These technologies are essential for ensuring high yields and purity of plasmids that carry genes of interest used in various expression systems. In cloning, plasmids serve as versatile vectors that facilitate the insertion of GOIs into host cells, which can be used for the production of recombinant proteins. For instance, the food and beverage industry use enzymes modified through recombinant DNA technology.

The transfection & gene editing segment is expected to grow at the fastest CAGR of 12.43% over the forecast period, driven by the increasing demand for effective gene delivery systems and innovative editing technologies. Plasmids serve as essential vectors in transfection processes, facilitating the introduction of genetic material into target cells. In gene editing, techniques like CRISPR-Cas9, which relies on plasmid vectors to deliver guide RNAs and Cas9 proteins, have shown remarkable efficiency in editing specific genomic locations. As gene editing applications expand into clinical settings, robust, scalable, and safe plasmid systems become increasingly critical, further driving the demand for advanced purification methods.

Regional Insights

North America dominated the plasmid purification market with the largest revenue share of 40.58% in 2023, owing to the advancements in research related to molecular cloning, the introduction of innovative technologies, and the increasing commercial demand for molecular cloned products. Furthermore, the region benefits from substantial research and development investments in cell & gene therapy, government funding for biotechnology and healthcare research, and highly advanced healthcare infrastructure.

U.S. Plasmid Purification Market Trends

The plasmid purification market in the U.S. is expected to grow at the fastest CAGR over the forecast period, due to the robust research and development landscape in biotechnology and life sciences, harnessing innovation & technological advancements in molecular cloning techniques, and the presence of key players in the country.

Europe Plasmid Purification Market Trends

The plasmid purification market in the Europe is expected to grow at the fastest CAGR over the forecast period. Europe's market was identified as a lucrative region in this industry. Strong research & development in biology, pharmaceuticals, and therapeutics, along with the presence of key market players in the region, are factors driving market growth.

The UK plasmid purification market is expected to grow at a significant CAGR over the forecast period. The rise in demand for personalized medicine, increased prevalence of chronic and hereditary diseases, and the surge in gene therapies have propelled the use of gene cloning techniques in the country. Furthermore, government laws regarding genetically modified crops are likely to boost the market growth. For instance, in March 2023, the Government of England legalized the commercial production of gene-edited food. Thus, using rDNA technology, scientists can enhance agricultural outcomes & food production.

The plasmid purification market in Germany is expected to grow at a substantial CAGR over the forecast period, driven by factors such as increased demand for molecularly cloned products, advancements in cloning technologies, and rising research and development investments in biotechnology sectors.

The France plasmid purification market is anticipated to grow at the fastest CAGR over the forecast period, due to increasing investments in research and development, advancements in biotechnology, and a growing emphasis on cell & gene therapy and precision medicine approaches for cancer treatment.

Asia Pacific Plasmid Purification Market Trends

Theplasmid purification market in Asia Pacific is anticipated to witness at the fastest CAGR of 13.66% from 2024 to 2030, due to the rising prevalence of chronic diseases, increasing research activities, advancements in genetic engineering, rising adoption of gene therapies, and a strong presence of biotechnology and biopharmaceutical companies in the region.

The Japan plasmid purification market is anticipated to grow at a significant CAGR over the forecast period. The increasing demand for recombinant DNA technique products, advancement in molecular engineering, and the rising demand for therapeutic products are some of the factors expected to propel market growth.

The plasmid purification market in China is expected to grow at a significant CAGR over the forecast period, owing to the increasing investments in healthcare innovation and research. The country’s focus on advancing biotechnology and cell & gene therapy, coupled with the rising awareness of personalized medicine, is driving the expansion of the market in China.

The India plasmid purification market is anticipated to grow at a rapid CAGR over the forecast period, due to the increasing demand for recombinant DNA technology products, the presence of biopharmaceutical companies involved in vaccine development further boosts market growth, and the rise of government investment in research activities. The advancement of molecular engineering and increasing scientific understanding of therapeutic products used to treat various disorders also contribute to market growth.

Middle East & Africa Plasmid Purification Market Trends

The plasmid purification market in the Middle East and Africa is projected to grow at the fastest CAGR during the forecast period, due to the increasing awareness and adoption of cloning techniques for the development of recombinant proteins, enzymes, and novel therapeutic tools to combat rising chronic disease prevalence in the region.

The Saudi Arabia plasmid purification market is expected to grow at a significant CAGR over the forecast period, due to substantial investment in biotechnology, increased research activities, and government initiatives supporting scientific advancements.

The plasmid purification market in Kuwait is anticipated to witness at a substantial CAGR over the forecast period. Kuwaiti institutions are actively collaborating with international researchers and companies in biotechnology research. This collaboration facilitates knowledge transfer and access to cutting-edge technologies, potentially accelerating the market's growth.

Key Plasmid Purification Company Insights

Key players operating in the global market are undertaking various initiatives to strengthen their market presence and increase the reach of their products and services. Strategies such as expansion activities and partnerships are playing a key role in propelling the market growth.

Recent Developments

• In June 2024, Thermo Fisher Scientific, Inc. launched the KingFisher PlasmidPro Maxi Processor (PlasmidPro), a maxi-scale plasmid DNA purification system that leverages the company’s KingFisher instrument portfolio

• In June 2024, Asahi Kasei Group’s U.S. subsidiary Bionova Scientific (a biologics CDMO) announced to set up a new plasmid DNA development & manufacturing facility in Texas, U.S.

• In April 2024, Charles River Laboratories signed a manufacturing contract with Axovia Therapeutics and Ship of Thesus. With this deal, Charles River will manufacture the gene-of-interest plasmid to support Axovia’s gene therapies for ciliopathies

• In June 2023, GenScript Biotech Corporation added the AmMag Quatro automated plasmid purification system to its lab and research product line-up, which can be used for viral vector development for cell engineering and gene therapy

• In February 2023, AccuraBio partnered with Cytiva to expand its plasmid DNA CDMO services, which uses Cytiva’s bacterial plasmid two-step purification program

• In June 2021, Thermo Fisher Scientific opened its facility in Carlsbad, California, to produce plasmid DNA for the DNA therapy and RNA vaccine industries

Plasmid Purification Market Report Scope

Global Plasmid Purification Market Report Segmentation

This report forecasts revenue growth at global, regional, and country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2018 to 2030. For this study, Grand View Research has segmented the global plasmid purification market report based on product & service, grade, application, end-use, and region.

• Product & Service Outlook (Revenue, USD Million, 2018 - 2030)

  • Products

    • Instruments

    • Kits & Reagents

  • Services

• Grade Outlook (Revenue, USD Million, 2018 - 2030)

  • Molecular Grade

  • Transfection Grade

• Application Outlook (Revenue, USD Million, 2018 - 2030)

  • Cloning & Protein Expression

  • Transfection & Gene Editing

  • Others

• End-use Outlook (Revenue, USD Million, 2018 - 2030)

  • Pharmaceutical & Biotechnology Companies

  • Academic & Research Institutes

  • Contract Research Organizations

• Regional Outlook (Revenue, USD Million, 2018 - 2030)

  • North America

    • U.S.

    • Canada

    • Mexico

  • Europe

    • Germany

    • UK

    • France

    • Italy

    • Spain

    • Denmark

    • Sweden

    • Norway

  • Asia Pacific

    • China

    • Japan

    • India

    • South Korea

    • Australia

    • Thailand

  • Latin America

    • Brazil

    • Argentina

  • MEA

    • South Africa

    • Saudi Arabia

    • UAE

    • Kuwait