High And Ultra-high-field Nuclear Magnetic Resonance Spectroscopy Market Size, Share & Trends Analysis Report By Frequency (High-field NMR Spectroscopy, Ultra High-field NMR Spectroscopy), By Application, By End-use, By Region, And Segment Forecasts, 2024 - 2035

Market Size & Trends

The global high and ultra-high-field nuclear magnetic resonance spectroscopy market size was estimated at USD 528.37 million in 2023 and is projected to grow at a CAGR of 5.70% from 2024 to 2035. Market growth can be attributed to the increasing funding & investment initiatives for nuclear magnetic resonance (NMR) spectroscopy in biomedical research, the rising need for affordable generic medicines, the growing scope of NMR spectroscopy in non-healthcare sectors, aided with the rising adoption of the technique in medical diagnosis.

NMR spectroscopy is considered an effective method to assess crystalline & amorphous pharmaceuticals in the drug and its product. Hence, the development of generic drugs is expected to boost the requirement for NMR spectroscopy. Moreover, the presence of universities, product developers, and pharmaceutical companies’ service providers is driving the growth of NMR spectroscopy. The essential processes in the pharmaceutical industry are the characterization of drug substances, identifying the structure of crystalline, and observing form conversion during active pharmaceutical ingredient (API) scale-up. Solid-state NMR (SSNMR) spectroscopy is considered an analytical tool for investigating multiple crystalline forms in an API and a drug product. Hence, the demand for NMR spectroscopy is anticipated to increase significantly with growing drug development activities.

NMR Spectroscopy is advancing its presence in diagnostics through biomedical research, such as the study of peptides, proteins, nucleic acids, and amino acids. The technique can analyze the dynamics, structure, and interactions of macromolecules. Hence, increasing research in the biomedical field is anticipated to enhance the use of NMR spectroscopy. According to a report published by WHO in February 2023, the number of funders and their contribution to biomedical research has been growing since 2012. In 2020, approximately 74,702 grants were allotted for biomedical research. The National Institutes of Health contributed the largest grants out of the total granted amount for biomedical research. Hence, the increasing number of grants for biomedical research is anticipated to drive the demand for NMR spectroscopy due to its wide use in biomedical research.

The NMR spectroscopy technique is widely employed in medical diagnosis. Nondestructiveness, noninvasiveness, and simplicity in sample preparation make NMR the ideal technique for metabolomics study. Furthermore, the diagnosis of Parkinson’s disease, cancer, & infectious and psychiatric disorders has been investigated using NMR spectroscopy. Various companies and academic participants are focusing on metabolomics-based diagnosis using NMR. For instance, in January 2022, the University of Oxford developed a new blood test using NMR metabolomics to identify various cancers. According to an article published by GenomeWeb in October 2021, Lifespin, a metabolomics testing firm, used NMR to develop metabolomics-based diagnostics. The company reported that its scientists had developed NMR-based metabolomic profiles of around 130,000 people, spanning a variety of disorder cohorts, which can help them develop a metabolomics-based diagnosis. Hence, the increasing focus of leading players and academic institutions on NMR for metabolomics diagnosis is anticipated to drive growth over the forecast period.

Market Concentration & Characteristics

The degree of innovation in the market is high, representing a significant advancement in the field of structural biology, metabolomics, and material science. The introduction of GHz-class NMR spectrometers, capable of achieving magnetic fields up to 1.2 GHz, has revolutionized the resolution and sensitivity of NMR experiments. These advancements allow for the separation of complex spectra, enhancing the accuracy of structure determination and improving the detection of low-concentration samples. The development of these technologies is driven by the need for sensitivity and specificity in NMR experiments, overcoming the limitations imposed by the inherent low sensitivity of NMR.

The level of M&A activity in the market is moderate due to its concentration with a limited number of players. These entities engage in mergers and acquisitions to enhance their industry standing, thereby strengthening their capabilities and competencies. For instance, in April 2022, Bruker acquired the UK-based Optimal Industrial Automation and Technologies. The tools and automation capabilities of acquired companies are expected to complement Bruker Corporation’s novel and differentiated high-value NMR instruments.

Regulations have a high impact on the market. Regulations play a crucial role in the NMR Spectroscopy market, affecting its competitive landscape by limiting the number of competitors and protecting established players' interests. Compliance with these regulations can be challenging and costly, impacting companies' profitability. However, favorable guidance and policies from regulatory authorities for utilizing NMR spectroscopy in medical applications are expected to boost the industry over the next decade. Yet, changes in regulations introduce uncertainties for industry participants, potentially requiring significant investments to meet new compliance requirements.

The threat of substitutes is expected to be high in this market due to the presence of external substitutes such as mass spectrometry and High-performance Liquid Chromatography (HPLC) with conventional ultraviolet detection. However, fewer benefits associated with the use of these substitutes decrease the threat to a certain level, leading to a moderate overall threat.

Regional expansion in the market is characterized by significant growth opportunities across different regions. North America, particularly the U.S., holds a substantial share due to the presence of numerous universities and government funding support for enhancing research infrastructure. Europe, led by countries such as the UK, Germany, France, Italy, and Spain, also contributes significantly to the market's growth.

Frequency Insights

Ultra-high-field NMR Spectroscopy (600-1200 MHz) segment led the market and accounted for 65.95% of the global revenue in 2023 driven by its advanced technological capabilities and expanding applications in various scientific fields. This range is crucial for detailed molecular and structural analysis, making it indispensable in pharmaceutical research, material science, & academic research. The pharmaceutical industry is a significant driver of the segment. As drug discovery processes become more complex, the need for detailed structural elucidation of large biomolecules such as proteins and nucleic acids increases. NMR in the 600 to 1.2 GHz range provides the detail -resolution and sensitivity data required to study these complex molecules. This capability is essential for understanding drug-target interactions, optimizing lead compounds, and ensuring the structural integrity of biologics.

High-field NMR Spectroscopy (300-600 MHz) segment held a significant market share in 2023 fueled by technological advancements and a surge in demand across various sectors. This range of NMR spectroscopy is extensively utilized in organic chemistry, biochemistry, and pharmaceuticals due to its ability to provide detailed molecular structure information. The market is projected to grow steadily, primarily driven by the expanding pharmaceutical and biotechnology industries. A significant driver is the need for precise structural analysis of compounds in drug discovery and development. In addition, the rise in academic research activities and increased investments in scientific research by governments and private organizations further contribute to market expansion.

Application Insights

Academic research segment led the market and accounted for 33.83% of the global revenue in 2023 In academic research it used across various disciplines, including structural biology, metabolomics, materials science, environmental science, and biomedical research. This technology provides detailed insights into a molecule’s structure, function, and interactions, significantly contributing to advancements in knowledge and innovation. In structural biology, NMR spectroscopy explains the three-dimensional structures of proteins and nucleic acids, offering critical insights into their functions and interactions.

Pharmaceutical application segment is projected to witness a significant growth rate over the forecast period. In the pharmaceutical industry, primarily it is used in comparative analysis, quantification, & quality control. The growing demand for NMR spectroscopy can be attributed to its ability to determine content and test purity in the sample. Furthermore, increasing penetration in chemical and biochemical labs to investigate the characteristics of organic molecules is expected to drive the NMR spectroscopy market.

End-use Insights

Academic led the market with a market share of 33.83% in 2023. High-field NMR spectroscopy significantly benefits academic research by providing detailed insights into molecular structures, assisting in drug discovery, & enhancing our comprehension of diseases such as cancer & Parkinson's. Its utility in structural biology and identifying complex molecules, including those associated with COVID-19, emphasizes its vital role in tackling global health issues. The rising demand in academic circles is likely to propel market growth, spurred by technological advancements and a growing focus on structural biology. Government funding for research infrastructure further boosts market expansion, emphasizing the crucial function of NMR in academic progress & market growth. For instance, in June 2021, The U.S. National Science Foundation (NSF) invested USD 40 million in a geographically distributed Network for Advanced Nuclear Magnetic Resonance to boost biomolecular research. This initiative, part of the NSF's Mid-Scale Research Infrastructure II program, sought to equip researchers with NMR spectrometers for studying biological systems and small molecules' structure, dynamics, and interactions.

Pharmaceutical and biotech companies’ segment is projected to witness a significant growth rate over the forecast period. Biotech and pharmaceutical companies are extensively utilizing technology in their operations, particularly in the early stages of drug discovery & development. This technology is crucial for assessing macromolecules' structure, dynamics, and interactions, essential for understanding the molecular basis of diseases & designing targeted therapies. Integrating NMR with other analytical techniques, such as mass spectrometry and chromatography, can enrich the data obtained, providing a comprehensive view of complex samples & systems. This multifaceted approach has contributed significantly to market growth, driven by the increasing demand for advanced analytical tools in the biotech and pharmaceutical sectors. For instance, in August 2022, Covalent Metrology installed a new 500 MHz NMR Spectrometer from JEOL. This installation enhanced Covalent's ability to support clients across various industries by providing solid-state & diffusion NMR services, including batteries, polymers, and carbon-capture materials.

Regional Insights

North America high and ultra-high-field nuclear magnetic resonance spectroscopy market is significantly growing, influenced by healthcare reforms and research advancements. This can be attributed to the presence of a well-established pharmaceutical industry and healthcare system in the U.S., which has created a significant demand for clinical & research purposes.

U.S. High And Ultra-high-field Nuclear Magnetic Resonance Spectroscopy Market Trends

The high and ultra-high-field nuclear magnetic resonance spectroscopy market in the U.S. is anticipated to be the lucrative growth during the forecast period, as it is the biggest market for biopharmaceuticals and a leader in biopharmaceutical R&D. According to the data published by PhRMA in 2022, member companies invested USD 102.3 billion in R&D of new medicines. Member companies have invested about USD 1.1 trillion in the R&D of new medicines over the last 20 years.

Europe High And Ultra-high-field Nuclear Magnetic Resonance Spectroscopy Market Trends

Europe high and ultra-high-field nuclear magnetic resonance spectroscopy market accounted for largest market share of 34.85% in 2023 can be attributed to the well-established pharmaceutical & biotechnology industries across Germany, the UK, and Italy and increasing demand for technology. Moreover, expanding biotechnology & pharmaceutical sector in countries, such as Spain and Russia, is expected to create a conducive environment for market growth in Europe. In addition, continuous research initiatives being undertaken by European manufacturers for the development of new and innovative NMR solutions are anticipated to create lucrative opportunities for market growth.

The UK high and ultra-high-field nuclear magnetic resonance spectroscopy market is witnessing significant developments and a growth trend, driven by presence of established R&D infrastructure and investments by the government are some key factors driving the market growth in the UK. Resources, tools, and facilities needed by researchers and innovators to carry out groundbreaking work in the UK are supported by the UKRI Infrastructure.

The high And ultra-high-field nuclear magnetic resonance spectroscopy market in France is poised for growth, driven by research and development in biological sciences. As a result of this vibrant atmosphere, several exceptional businesses have developed, reaching the value chain.

The Germany high and ultra-high-field nuclear magnetic resonance spectroscopy market is driven by favorable government regulations, advanced healthcare infrastructure, rising number of drug & device approvals, and growing concerns regarding food safety are some key factors driving market.

Asia Pacific High And Ultra-high-field Nuclear Magnetic Resonance Spectroscopy Market Trends

The Asia Pacific high and ultra-high-field nuclear magnetic resonance spectroscopy market is experiencing significant growth attributed to the expansion of the pharmaceutical & biotechnology industries in emerging economies, such as China and India. The robust growth is further propelled by consistent government support for the advancement of the pharmaceutical sector in developing nations.

The China high and ultra-high-field nuclear magnetic resonance spectroscopy market is expected to grow at a lucrative rate during the forecast period. This can be attributed to the robust growth of pharmaceutical, biotechnology, and biopharmaceutical sectors in China.

The high and ultra-high-field nuclear magnetic resonance spectroscopy market in Japan has experienced considerable development, positioning Japan to hold a substantial share of the Asia Pacific market. This is largely attributed to Japan's developed pharmaceutical and biotechnology sectors, which drive the demand for advanced analytical tools.

Latin America High And Ultra-high-field Nuclear Magnetic Resonance Spectroscopy Market Trends

The Latin America high and ultra-high-field nuclear magnetic resonance spectroscopy market is influenced by technological advancements, increasing government expenditure on R&D, the presence of skilled healthcare professionals, and rising focus of multinational pharmaceutical companies on analytical instruments.

The high and ultra-high-field nuclear magnetic resonance spectroscopy market in Brazil is attributed to the presence of an established pharmaceutical industry compared to other countries in Latin America. Furthermore, increasing public-private initiatives to facilitate access to advanced NMR spectroscopy solutions are expected to drive market growth.

Middle East & Africa High and Ultra-high-field Nuclear Magnetic Resonance Spectroscopy Market Trends

The Middle East & Africa (MEA) high and ultra-high-field nuclear magnetic resonance spectroscopy market is experiencing a gradual increase in the adoption. Key countries such as Saudi Arabia, the UAE, Qatar, South Africa, and Egypt are actively integrating state-of-the-art NMR technology into their scientific research infrastructures.

The high and ultra-high-field NMR spectroscopy market growth in Saudi Arabia can be attributed to various initiatives being undertaken by the government to expand the biotechnology sector in the country. Organizations such as King Saud University (KSU) and King Abdullah University of Science & Technology (KAUST) are focusing on investing to facilitate biotechnology R&D activities in Saudi Arabia. Moreover, the increasing private & public partnerships for expanding the biopharmaceutical industry are anticipated to boost the demand for products.

Key High And Ultra-high-field Nuclear Magnetic Resonance Spectroscopy Company Insights

The market is largely driven by two major players, Bruker Corporation and JEOL Ltd. These players are adopting acquisitions and other strategies to strengthen their presence in other regional markets.

Recent Developments

• In December 2023, Bruker Corporation successfully installed a 1.2 GHz NMR system at Ohio State University’s National Gateway Ultrahigh Field NMR Center. This advanced system would significantly enhance the center’s research capabilities, enabling groundbreaking studies in structural biology, materials science, and related fields by providing unprecedented resolution and sensitivity in NMR spectroscopy.

• In April 2023, JEOL Ltd. introduced the Cryogen Reclamation System, an NMR peripheral equipment, to decrease the evaporation of liquid helium in the superconducting magnet. JEOL Ltd. and Japan Superconductor Technology, Inc. jointly developed this product.

• In April 2023, Bruker Corporation unveiled magnet technology and analytical solutions to enhance the adoption of NMR in academic research, clinical studies, biopharma drug discovery & development, and process analytical technologies.

High And Ultra-high-field Nuclear Magnetic Resonance Spectroscopy Market Report Scope

Global High And Ultra-high-field Nuclear Magnetic Resonance Spectroscopy Market Report Segmentation

This report forecasts revenue growth at global, regional, and country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2018 to 2030. For this study, Grand View Research has segmented the global high and ultra-high-field nuclear magnetic resonance spectroscopy market report based on frequency, application, end-use, and region:

• Frequency Outlook (Revenue, USD Million, 2018 - 2030)

  • High-field NMR Spectroscopy (300-600 MHz)

  • Ultra-high-field NMR Spectroscopy(600-1,200 MHz)

    • 600

    • 700

    • 800

    • 900

    • 1000

    • 1200

• Application Outlook (Revenue, USD Million, 2018 - 2030)

  • Pharmaceutical Applications

  • Food & Beverage Testing

  • Biotechnology & Biopharmaceutical Applications

  • Environmental Testing, Academic Research

  • Other Applications

• End-use Outlook (Revenue, USD Million, 2018 - 2030)

  • Academic

  • Pharmaceutical & Biotech Companies

  • Agriculture And Food

  • Chemical Industries

  • Others

• Regional Outlook (Revenue, USD Million, 2018 - 2030)

  • North America

    • U.S.

    • Canada

    • Mexico

  • Europe

    • Germany

    • UK

    • France

    • Italy

    • Spain

    • Denmark

    • Sweden

    • Norway

  • Asia Pacific

    • China

    • Japan

    • India

    • South Korea

    • Australia

    • Thailand

  • Latin America

    • Brazil

    • Argentina

  • Middle East and Africa (MEA)

    • South Africa

    • Saudi Arabia

    • Kuwait

    • UAE