Europe Recombinant Protein Manufacturing Services Market Size, Share & Trends Analysis Report By Service Type (Pre-clinical & Clinical), By Host Cell (Mammalian, Bacterial), By End-use, By Country, And Segment Forecasts, 2023 - 2030

Report Overview

The Europe recombinant protein manufacturing services market size was estimated at USD 1.06 billion in 2022 and is expected to grow at a compound annual growth rate (CAGR) of 14.88% from 2023 to 2030. The increasing outsourcing for recombinant protein manufacturing, the growing preference for biologics & biosimilars, the high prevalence of chronic disorders, and the increasing application of recombinant proteins are expected to boost market expansion. According to the European Society for Medical Oncology, an estimated 1,269,200 cancer deaths were reported in Europe in 2022. As recombinant proteins are widely used in research and diagnosis of cancer, an upsurge in the cancer burden is projected to boost the demand for proteins, driving market growth.

Moreover, the high burden of cancer creates a need for advanced therapeutics, leading to increased adoption of outsourcing services to produce advanced therapies such as recombinant proteins.

Recombinant protein production is a cost-intensive process that requires specialized facilities and large-scale production capabilities. Several challenges concerning regulatory compliance and adherence to manufacturing standards can further increase the complexities associated with the production of protein-based products. As a result, the trend toward outsourcing protein production to leverage the expertise and capabilities of CMOs in this domain has been increasing in recent years. Furthermore, certain specialized and repetitive activities, such as fill/finish, analytical testing/bioassays, and toxicology testing, are outsourced to a greater extent in the biopharmaceutical industry.

In the diagnostics domain, recombinant proteins find applications in immunoassays and molecular diagnostics for the detection & monitoring of various diseases. For instance, recombinant antigens and enzymes can be used for precise & sensitive identification of biomarkers and pathogens. Recombinant proteins are also increasingly used for industrial-scale applications. For instance, enzymes derived from recombinant DNA technology offer distinct advantages, such as enhanced efficacy, stability, and specificity, which makes them useful for the downstream processing of fermentation-based pharmaceutical products.

In addition, with the ongoing advancements in recombinant technology, novel applications of recombinant proteins for developing personalized medicine, cell & gene therapies, and bioengineering products are projected to increase. For instance, gene editing technologies, such as CRISPR-Cas9, have enabled the precise alteration of proteins to create innovative therapeutics. These factors are expected to significantly increase the demand for proteins, driving the market for manufacturing services.

Service Type Insights

Commercial production services was the largest revenue-generating segment with the dominant market share of 58.82% in 2022. The development of recombinant DNA technology, cell culture methods, protein expression systems, and growing accessibility of high-yield expression systems like mammalian cell lines, yeast, and bacteria, which can boost production productivity & efficiency, are some of the factors driving the commercial production services market.

The commercial production services segment is expected to witness the fastest CAGR of 16.39% over the forecast period due to an increasing focus on precision medicine, targeted therapies, and the growing need for outsourcing clinical trial design, data collection, & analysis. Moreover, Europe is home to some of the world’s high research and development (R&D) focused countries, such as the UK, Germany, and Denmark. For instance, according to EuroDev, the pharmaceutical industry in Germany spends over USD 6.74 billion (EUR 6.2 billion) annually on R&D and conducted around 499 clinical trials funded by research-based pharmaceutical companies in 2019. This is expected to drive market expansion throughout the forecast period.

Host Cell Insights

Mammalian host cell was the highest revenue-generating segment with the largest market share of 54.70% in 2022. For manufacturing complex proteins that need significant folding, subunit assembly, and/or posttranslational modifications, mammalian cells are fitting host cells. These features contribute to understanding the preference for mammalian cells utilized in the biotech and pharmaceutical sectors for manufacturing diagnostic and therapeutic proteins.

On the other hand, the yeast & fungi segment is estimated to witness a significant CAGR of 16.29% over the forecast period.Yeasts are now used in several healthcare fields, including the generation of therapeutic recombinant proteins and their traditional application in fermentation. Yeast cells are particularly captivating as hosts for biopharmaceutical synthesis as they are generally accepted as safe organisms. These factors are expected to drive market expansion throughout the forecast period.

End-use Insights

The pharmaceutical & biotechnology company segment held the largest market share of 78.79% in 2022. Numerous major and small biotechnology businesses are driving innovation in these fields in terms of service and manufacturing capabilities, providing commercial potential for market expansion.  For instance, the EIB approved a USD 19.65 million (€18 million) investment to Estonian biotech Icosagen for new Current Good Manufacturing Practice (cGMP) production facilities and novel Research & Development (R&D) technologies. Furthermore, rising demand for protein manufacturing services, growing competition among players, and increasing biologics pipeline are contributing to the development of the global market.

On the other hand, the academic & research institutes industry segment is estimated to witness a 17.34% CAGR during the forecast period.As recombinant technology advances, novel uses of recombinant proteins enabling the development of customized medicine, cell and gene therapies, and bioengineering products are expected to grow at a rapid rate. For example, the development of gene editing technologies such as CRISPR-Cas9 permitted precise modification of recombinant proteins to develop novel therapies. These factors are projected to significantly improve the demand for recombinant proteins in academic and research institutes, driving the segment’s growth in the manufacturing services industry.

Country Insights

Germany held the dominant revenue share of 17.95% in 2022, attributed to increased research spending, the availability of well-established healthcare infrastructure, and the existence of several industry participants. These factors are expected to increase the demand for recombinant protein manufacturing services in the country.

The Netherlands is expected to experience the fastest CAGR of 21.94% over the forecast period due to improved healthcare infrastructure, improving economic factors, an increase in government efforts to raise awareness, as well as favorable regulatory policies that will boost the rate of adoption of manufacturing services. Furthermore, the region's increased need for high-quality healthcare has a favorable impact on the industry.

Key Companies & Market Share Insights

The continuous demand for recombinant protein manufacturing services by multiple applications has created numerous market opportunities for major players to capitalize on. For instance, in January 2023, AGC Biologics invested in a new dedicated facility in Copenhagen, Denmark, to increase its mammalian cell-culture capacity by two folds. Some prominent players in the Europe recombinant protein manufacturing services market include:

• Lonza

• Boehringer Ingelheim International GmbH

• FUJIFILM Diosynth Biotechnologies

• Merck KGaA

• Bruker (InVivo BioTech Services GmbH)

• Sino Biological, Inc.

• GenScript

• Kaneka corporation (Kaneka Eurogentec S.A)

• Polyplus Transfection (Xpress Biologics)

• Boster Biological Technology

• Trenzyme GmbH

Europe Recombinant Protein Manufacturing Services Market Report Scope

Europe Recombinant Protein Manufacturing Services Market Report

This report forecasts revenue growth and provides an analysis of the latest industry trends in each of the sub-segments from 2018 to 2030. For this study, grand view research has segmented the Europe recombinant protein manufacturing services market report based on service type, host cell, end-use, and country:

• Service Type Outlook (Revenue, USD Million, 2018 - 2030)

  • Pre-clinical & Clinical Services

  • Commercial Production Services

• Host Cell Outlook (Revenue, USD Million, 2018 - 2030)

  • Mammalian Cells

  • Bacterial Cells

  • Insect Cells

  • Yeast & Fungi

  • Others

• End-use Outlook (Revenue, USD Million, 2018 - 2030)

  • Pharmaceutical & Biotechnology Companies

  • Academic & Research Institutes

• Country Outlook (Revenue, USD Million, 2018 - 2030)

  • Europe

    • Germany

    • UK

    • France

    • Italy

    • Spain

    • Denmark

    • Sweden

    • Norway

    • Switzerland

    • Netherlands