The global anti-vascular endothelial growth factor therapeutics market size was valued at USD 11.67 billion in 2020 and is expected to grow at a compound annual growth rate (CAGR) of 0.5% from 2021 to 2028. The anti-Vascular Endothelial Growth Factor (VEGF) therapeutics market growth can be attributed to an increase in the prevalence of ophthalmic diseases, such as macular edema, diabetic retinopathy, retinal vein occlusion, and Age-related Macular Degeneration (AMD), coupled with an increasing geriatric population that is exposed to the risk of developing the condition. According to the WHO, around 196 million people are affected by AMD globally, which includes over 10.4 million cases with moderate to severe vision impairment. In addition, product launches and research advancements are contributing to market growth.
AMD is the leading cause of vision loss among the Canadian population; it affected around 1.4 million people in 2018. In 2017, in the European Union, approximately 34 million people were estimated to suffer from AMD. In addition, the alarmingly increasing rate of diabetes prevalence globally is a major market driver. As per the Lancet journal, in 2018, the annual incidence of diabetic retinopathy ranges between 12.7% and 2.2%.
Moreover, with the growing geriatric population, the incidence of eye disorders is projected to increase over the coming years. According to WHO estimates, the number of people aged above 60 years has outnumbered the population of children aged 5 years. By the end of 2050, the geriatric population is estimated to be around 2 billion from 900 million in 2015. Furthermore, globally, 125 million people belong to the age group of 80 years and above.
The focus of market players is shifting to longer-acting VEGF products and treatments for these conditions. The recent launch of brolucizumab by Novartis in 2019 has increased competition among the existing drugs in the market. A longer-acting VEGF medication-Beovu (brolucizumab)-has been introduced, with an initial 3 monthly loading dose, which is later administered every 8 to 12 weeks.
Moreover, the companies are developing various formulations and drug delivery systems that may increase the adoption of these therapies. For instance, F. Hoffmann La Roche Ltd. is developing the port delivery system-RG6321 (Ranibizumab)-which is currently undergoing a phase III clinical trial. It is an eye implant that is refillable and continuously delivers a customized formulation of ranibizumab over a period of months.
However, low screening and diagnostic rates of diabetic retinopathy in developing nations adversely impact market growth. The high chances of intraocular injuries in anti-VEGF treatment are another factor acting as a market restraint. In addition, the patent cliff is one of the major issues in the pharmaceutical industry, as major blockbuster drugs typically account for a large percentage of company turnovers.
Key players in the market are involved in the development of biosimilar due to the patent expiry of Lucentis in the U.S. in June 2020 and in Europe in 2022. In November 2019, CoherusBioSciences, Inc. entered into a license and development agreement with Bioeq IP AG for the commercialization of Lucentis biosimilar in the U.S. The company is planning to introduce the product into the market in 2021, which is anticipated to increase the cost-effectiveness of the treatment, making it available to a larger target population.
The Eylea product segment dominated the global market in 2020 with a revenue share of over 67%. The segment is anticipated to retain its dominance throughout the forecast period. The product is expected to witness significant demand owing to advancements in formulations and the development of advanced drug delivery systems. In April 2020, Bayer AG announced the launch of Eylea injection prefilled syringes in the EU market, which is valid in all 27 EU member states.
This new formulation may increase product adoption by ophthalmologists due to its ease of administration. Beovuis anticipated witnessing the fastest CAGR over the forecast period owing to geographic expansion and patent exclusivity. In February 2020, Novartis AG announced EC approval for the launch of Beovu (brolucizumab) injection for treating WAMD. The EC approval applies to all 27 EU member states. The product approval in a new geographic region may increase sales of the product and expand the customer base.
The Age-related Macular Degeneration (AMD) segment accounted for the largest market share of more than 86% in 2020. The segment is expected to maintain the leading position over the forecast period owing to the increasing disease burden, growing geriatric population, and presence of late-stage product candidates that are expected to enter the market in the coming years. For instance, REGENXBIO Inc.’s pipeline candidate-RGX-314-is currently undergoing a phase II clinical trial and can be commercialized by the end of 2023.
The diabetic retinopathy segment is expected to grow at the fastest CAGR during the forecast years owing to unmet medical needs and an increasing number of treatment approvals for diabetic retinopathy. One-fifth of the diabetic population suffers from retinopathy, leading to 56% of visual impairment cases globally. In May 2019, Regeneron Pharmaceuticals received approval from the FDA for treating all stages of diabetic retinopathy which may fuel the growth of the segment.
North America region accounted for the highest revenue share of more than 64% of the global market in 2020. The regional market is expected to witness a significant growth rate over the forecast period. Factors, such as high disease prevalence, rising consumer awareness, proactive government measures, technological advancements, and improvements in healthcare infrastructure are expected to boost the regional market growth. The presence of key players in North America will also support the market growth. In May 2020, F. Hoffmann-La Roche Ltd. announced the top-line phase III clinical trial results for formulation advancement of ranibizumab with the Port Delivery System.
Such delivery systems with technological advancements and product launches are expected to positively impact the market growth in the region. Asia Pacific is expected to grow at the fastest CAGR of 2.4% from2021 and 2028. An increase in penetration of anti-VEGF products, rising disposable income, and growing consumer awareness are the key factors expected to drive the regional market growth. Furthermore, a rising number of initiatives, such as improving access to anti-VEGF medications through favorable reimbursement policies, undertaken by the governments for improving the health of the population may fuel the product adoption, thereby augmenting the regional market growth.
Key companies are adopting strategies that allow them to use their resources to aid in the development of new products. For instance, in December 2020, F. Hoffmann-La Roche Ltd. announced positive top-line results from global phase III studies evaluating faricimab in people with DME. Faricimab was well-tolerated with no safety signals identified. Some of the prominent players in the global anti-VEGF therapeutics market include:
F. Hoffmann-La Roche Ltd.
Biogen
Pfizer, Inc.
CoherusBioSciences
Amgen, Inc.
Bausch Health Companies, Inc.
Viatris, Inc.
Report Attribute |
Details |
Market size value in 2021 |
USD 12.36 billion |
Revenue forecast in 2028 |
USD 12.82 billion |
Growth rate |
CAGR of 0.5% from 2021 to 2028 |
Base year for estimation |
2020 |
Historical data |
2017 - 2019 |
Forecast period |
2021 - 2028 |
Quantitative units |
Revenue in USD million/billion and CAGR from 2021 to 2028 |
Report coverage |
Revenue forecast, company ranking, competitive landscape, growth factors, and trends |
Segments covered |
Product, disease, and region |
Regional scope |
North America; Europe Asia Pacific; Latin America; MEA |
Country scope |
U.S.; Canada; U.K.; Germany; France; Italy; Spain; India; China; Japan; Australia; Brazil; Mexico; Argentina; Saudi Arabia; UAE; South Africa |
Key companies profiled |
Regeneron Pharmaceuticals, Inc.; Bayer AG; Novartis AG; F. Hoffmann-La Roche Ltd.; Biogen; Pfizer, Inc.; CoherusBioSciences; Amgen, Inc.; Bausch Health Companies, Inc.; and Viatris, Inc. |
Customization scope |
Free report customization (equivalent up to 8 analysts working days) with purchase. Addition or alteration to country, regional & segment scope. |
Pricing and purchase options |
Avail customized purchase options to meet your exact research needs. Explore purchase options |
This report forecasts revenue growth at global, regional and country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2017 to 2028. For the purpose of this study, Grand View Research has segmented the global anti-vascular endothelial growth factor therapeutics market report on the basis of product, disease, and region:
Product Outlook (Revenue, USD Million, 2017 - 2028)
Eylea
Lucentis
Beovu
Disease Outlook (Revenue, USD Million, 2017 - 2028)
Macular Edema
Diabetic Retinopathy
Retinal Vein Occlusion
Age-related Macular Degeneration
Regional Outlook (Revenue, USD Million, 2017 - 2028)
North America
U.S.
Canada
Europe
U.K.
Germany
France
Italy
Spain
Asia Pacific
India
China
Japan
Australia
Latin America
Argentina
Brazil
Mexico
Middle East & Africa
Saudi Arabia
UAE
South Africa
b. The global anti-VEGF therapeutics market size was estimated at USD 11.67 billion in 2020 and is expected to reach USD 12.36 billion in 2021.
b. The global anti-VEGF therapeutics market is expected to witness a compound annual growth rate of 0.5% from 2020 to 2028 to reach USD 12.82 billion by 2028.
b. North America held the largest share of 64.8% in 2020 due to due to increase in disease prevalence, rise in customer awareness, technological advancements, proactive government initiatives, and improved healthcare infrastructure.
b. Key players in the market for global anti-vascular endothelial growth factor therapeutics include Regeneron Pharmaceuticals, Inc.; Bayer AG; and Novartis AG. Other key companies operating in anti-VEGF therapeutics market are F. Hoffmann-La Roche Ltd; Biogen; Pfizer, Inc.; Coherus BioSciences; Amgen, Inc.; Bausch Health Companies, Inc.; and Viatris, Inc.
b. Key factors driving the global anti-vascular endothelial growth factor therapeutics market include technological advancements in ophthalmic diseases treatment, rise in prevalence of ophthalmic & chronic diseases associated with indications such as age-related macular degeneration, retinal vein occlusion, diabetic retinopathies, and increase in per capita healthcare expenditure across the globe.
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