U.S. Pulmonary Arterial Hypertension Market Size & Outlook

The pulmonary arterial hypertension market in the United States is expected to reach a projected revenue of US$ 3,829.1 million by 2030. A compound annual growth rate of 4.7% is expected of the United States pulmonary arterial hypertension market from 2024 to 2030.
Revenue, 2023 (US$M)
$2,772.0
Forecast, 2030 (US$M)
$3,829.1
CAGR, 2024 - 2030
4.7%
Report Coverage
U.S.

U.S. pulmonary arterial hypertension market, 2018-2030 (US$M)

U.S.

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U.S. pulmonary arterial hypertension market highlights

  • The U.S. pulmonary arterial hypertension market generated a revenue of USD 2,772.0 million in 2023 and is expected to reach USD 3,829.1 million by 2030.
  • The U.S. market is expected to grow at a CAGR of 4.7% from 2024 to 2030.
  • In terms of segment, prostacyclin and prostacyclin analogs was the largest revenue generating drug class in 2023.
  • SGC Stimulators is the most lucrative drug class segment registering the fastest growth during the forecast period.


Pulmonary arterial hypertension market data book summary

Market revenue in 2023USD 2,772.0 million
Market revenue in 2030USD 3,829.1 million
Growth rate4.7% (CAGR from 2023 to 2030)
Largest segmentProstacyclin and prostacyclin analogs
Fastest growing segmentSGC Stimulators
Historical data2018 - 2022
Base year2023
Forecast period2024 - 2030
Quantitative unitsRevenue in USD million
Market segmentationEndothelin Receptor Antagonists (ERAs), PDE-5 Inhibitors, Prostacyclin and Prostacyclin Analogs, SGC Stimulators
Key market players worldwideUnited Therapeutics Corp, Bayer AG, Gilead Sciences Inc, Johnson & Johnson, Viatris Inc, GlaxoSmithKline, Sandoz Group AG ADR, Lupin, Sun Pharmaceutical Industries, Teva Pharmaceutical Industries Ltd


Other key industry trends

  • In terms of revenue, U.S. accounted for 37.6% of the global pulmonary arterial hypertension market in 2023.
  • Country-wise, U.S. is expected to lead the global market in terms of revenue in 2030.
  • In North America, U.S. pulmonary arterial hypertension market is projected to lead the regional market in terms of revenue in 2030.
  • Canada is the fastest growing regional market in North America and is projected to reach USD 675.3 million by 2030.

Prostacyclin and prostacyclin analogs was the largest segment with a revenue share of 47.47% in 2023. Horizon Databook has segmented the U.S. pulmonary arterial hypertension market based on endothelin receptor antagonists (eras), pde-5 inhibitors, prostacyclin and prostacyclin analogs, sgc stimulators covering the revenue growth of each sub-segment from 2018 to 2030.


The U.S. is market leader in the PAH drugs, accounting for USD 2,772.17 Million in 2020 and anticipated to grow at a rate of 4.2% over the forecast period. Availability, of branded drugs in the U.S. coupled with supportive legislation for rare diseases and orphan drugs contributed remunerative growth of this region.

The Orphan Drug Act (ODA) 1983, and Rare Disease Act 2002 are the two most important acts that facilitate the ethical distribution and usage of orphan drugs.  With the help of organizations such as the National Organization of Rare Disorders, the development of orphan drugs is promoted, which have a smaller market share.

Several companies are undertaking initiatives related to progress in the pulmonary arterial hypertension market. For instance, in June 2020, Bayer U.S. launched the Second Annual Pulmonary Hypertension Accelerated Bayer Awards to support, encourage, and recognize innovation in research in Pulmonary Hypertension (PH).

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U.S. pulmonary arterial hypertension market size, by drug class, 2018-2030 (US$M)

U.S. Pulmonary Arterial Hypertension Market Outlook Share, 2023 & 2030 (US$M)

U.S. pulmonary arterial hypertension market size, by drug class, 2018-2030 (US$M)

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