U.S. Gene Therapy Market Size & Outlook, 2023-2030
- Biotechnology
- Gene Expression & Gene Therapy
- Gene Therapy Market Outlook
- Gene Expression & Gene Therapy
U.S. Gene Therapy Market, 2018-2030 (US$M)
Global Market
Related Markets
U.S. gene therapy market highlights
- The U.S. gene therapy market generated a revenue of USD 5,533.7 million in 2023 and is expected to reach USD 18,484.0 million by 2030.
- The U.S. market is expected to grow at a CAGR of 18.8% from 2024 to 2030.
- In terms of segment, other vector type was the largest revenue generating vector type in 2023.
- AAV is the most lucrative vector type segment registering the fastest growth during the forecast period.
Gene therapy market data book summary
| Market revenue in 2023 | USD 5,533.7 million |
| Market revenue in 2030 | USD 18,484.0 million |
| Growth rate | 18.8% (CAGR from 2024 to 2030) |
| Largest segment | Other vector type |
| Fastest growing segment | AAV |
| Historical data | 2018 - 2022 |
| Base year | 2023 |
| Forecast period | 2024 - 2030 |
| Quantitative units | Revenue in USD million |
| Market segmentation | Lentivirus, AAV, RetroVirus & gamma RetroVirus, Modified Herpes Simplex Virus, Other Vector Type |
| Key market players worldwide | Regenxbio Inc, Oxford Biomedical Research, Bristol-Myers Squibb Co, Sanofi SA, Ultragenyx Pharmaceutical Inc, Roche Holding AG ADR, Bluebird bio Inc, Novartis AG ADR, UniQure NV, Cellectis SA, Sangamo Therapeutics Inc, Benitec Biopharma Inc, SiBiono GeneTech, Transgene SA, Gensight Biologics SA, Astellas Pharma Inc |
Other key industry trends
- In terms of revenue, U.S. accounted for 64.5% of the global gene therapy market in 2023.
- Country-wise, U.S. is expected to lead the global market in terms of revenue in 2030.
- In North America, U.S. gene therapy market is projected to lead the regional market in terms of revenue in 2030.
- U.S. is the fastest growing regional market in North America and is projected to reach USD 18,484.0 million by 2030.
The U.S. is the largest market for clinical trials related to gene therapy, as around 50% of all clinical trials in the world are conducted in the country. As of March 2023, more than 2,500 clinical studies are under investigation in the U.S. alone.
A large number of gene therapy trials focus on finding feasible treatment options for cancer, closely followed by genetic diseases and neurological disorders.
The local presence of several large companies and small startups—working on the development of gene therapies—and partnerships & mergers between them are anticipated to boost the market.
Key Regions:U.S., UK, Japan, South Korea, China
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Publish Date: Mar 17, 2025
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Gene Therapy Market Scope
Gene Therapy Market Companies
| Name | Profile | # Employees | HQ | Website |
|---|---|---|---|---|
| Novartis AG ADR | View profile | 76,057 | Lichtstrasse 35, Basel, Switzerland, 4056 | www.novartis.com |
| Roche Holding AG ADR | View profile | 103,605 | Grenzacherstrasse 124, Basel, Switzerland, 4070 | www.roche.com |
| Sanofi SA | View profile | 87,994 | 46, avenue de la Grande Armée, Paris, France, 75017 | www.sanofi.com |
| Bristol-Myers Squibb Co | View profile | 34,100 | Route 206 and Province Line Road, Princeton, New Jersey, NJ, United States, 08543 | www.bms.com |
| UniQure NV | View profile | 480 | Paasheuvelweg 25, Amsterdam, NH, Netherlands, 1105 BP | www.uniqure.com |
| SiBiono GeneTech | View profile | 1001-5000 | Shenzhen, Guangdong, China, Asia | www.sibiono.com |
| Cellectis SA | View profile | 216 | 8, rue de la Croix Jarry, Paris, France, 75013 | www.cellectis.com |
| Astellas Pharma Inc | View profile | 14,484 | 2-5-1, Nihonbashi-Honcho, Chuo-ku, Tokyo, Japan, 103-8411 | www.astellas.com |
| Bluebird bio Inc | View profile | 323 | 455 Grand Union Boulevard, Somerville, MA, United States, 02145 | www.bluebirdbio.com |
| Sangamo Therapeutics Inc | View profile | 405 | 501 Canal Boulevard, Richmond, CA, United States, 94804 | www.sangamo.com |
U.S. Gene Therapy Market Outlook
The databook is designed to serve as a comprehensive guide to navigating this sector. The databook focuses on market statistics denoted in the form of revenue and y-o-y growth and CAGR across the globe and regions. A detailed competitive and opportunity analyses related to Gene Therapy Market Outlook will help companies and investors design strategic landscapes.
Other Vector Type was the largest segment with a revenue share of 47.62% in 2023.
Horizon Databook has segmented the U.S. gene therapy market based on lentivirus, aav, retrovirus & gamma retrovirus, modified herpes simplex virus, other vector type covering the revenue growth of each sub-segment from 2018 to 2030.
The U.S. is the largest market for clinical trials related to gene therapy, as around 50% of all clinical trials in the world are conducted in the country. As of March 2023, more than 2,500 clinical studies are under investigation in the U.S. alone.
A large number of gene therapy trials focus on finding feasible treatment options for cancer, closely followed by genetic diseases and neurological disorders.
The local presence of several large companies and small startups—working on the development of gene therapies—and partnerships & mergers between them are anticipated to boost the market.
- U.S. Gene Therapy Market Vector Type Outlook (Revenue, USD Million , 2018-2030)
- Lentivirus
- AAV
- RetroVirus & gamma RetroVirus
- Modified Herpes Simplex Virus
- Adenovirus
- Non-viral Plasmid Vector
- Other Vector Type
- U.S. Gene Therapy Market Indication Outlook (Revenue, USD Million , 2018-2030)
- Acute Lymphoblastic Leukemia (ALL)
- Inherited Retinal Disease
- Large B-cell Lymphoma
- ADA-SCID
- Melanoma (lesions)
- Beta-Thalassemia Major/SCD
- Head & Neck Squamous Cell Carcinoma
- Peripheral arterial disease
- Spinal Muscular Atrophy (SMA)
- Others
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Horizon Databook provides a detailed overview of country-level data and insights on the U.S. Gene Therapy Market Outlook, including forecasts for subscribers. This country databook contains high-level insights into U.S. Gene Therapy Market Outlook from 2018 to 2030, including revenue numbers, major trends, and company profiles.
U.S. Gene Therapy Market, 2018-2030 (US$M)
U.S. gene therapy market statistics, by vector type, 2018-2030 (US$M)
