North America Hereditary Angioedema Therapeutics Market Size & Outlook
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North America hereditary angioedema therapeutics market highlights
- The North America hereditary angioedema therapeutics market generated a revenue of USD 1,422.1 million in 2025.
- The market is expected to grow at a CAGR of 8.3% from 2026 to 2033.
- In terms of segment, kallikrein inhibitor was the largest revenue generating treatment in 2025.
- Kallikrein inhibitor is the most lucrative treatment segment registering the fastest growth during the forecast period.
- Country-wise, Canada is expected to register the highest CAGR from 2026 to 2033.
North America data book summary
| Market revenue in 2025 | USD 1,422.1 million |
| Market revenue in 2033 | USD 2,762.4 million |
| Growth rate | 8.3% (CAGR from 2026 to 2033) |
| Largest segment | Kallikrein inhibitor |
| Fastest growing segment | Kallikrein inhibitor |
| Historical data covered | 2021 - 2024 |
| Base year for estimation | 2025 |
| Forecast period covered | 2026 - 2033 |
| Quantitative units | Revenue in USD million |
| Market segmentation | C1-Inhibitor Concentrates, Bradykinin B2 receptor antagonist, Kallikrein inhibitor |
| Key market players worldwide | BioCryst Pharmaceuticals Inc, Ionis Pharmaceuticals Inc, CSL Ltd, Adverum Biotechnologies Inc, KalVista Pharmaceuticals Inc, Takeda Pharmaceutical Co Ltd, Pharming Group, Attune Pharmaceuticals |
Other key industry trends
- In terms of revenue, North America region accounted for 39.5% of the global hereditary angioedema therapeutics market in 2025.
- Globally, North America is projected to lead the regional market in terms of revenue in 2033.
- Asia Pacific is the fastest growing regional market and is projected to reach USD 2,045.0 million by 2033.
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Hereditary Angioedema Therapeutics Market Scope
Hereditary Angioedema Therapeutics Market Companies
| Name | Profile | # Employees | HQ | Website |
|---|---|---|---|---|
| Attune Pharmaceuticals | View profile | 1-10 | New York, New York, United States, North America | http://attunepharma.com/ |
| Pharming Group | View profile | 382 | Darwinweg 24, Leiden, ZH, Netherlands, 2333 CR | https://www.pharming.com |
| KalVista Pharmaceuticals Inc | View profile | 118 | 55 Cambridge Parkway, Suite 901 East, Cambridge, MA, United States, 02142 | https://www.kalvista.com |
| Adverum Biotechnologies Inc | View profile | 121 | 100 Cardinal Way, Redwood CIty, CA, United States, 94063 | https://www.adverum.com |
| BioCryst Pharmaceuticals Inc | View profile | 531 | 4505 Emperor Boulevard, Suite 200, Durham, NC, United States, 27703 | https://www.biocryst.com |
| Ionis Pharmaceuticals Inc | View profile | 927 | 2855 Gazelle Court, Carlsbad, CA, United States, 92010 | https://www.ionispharma.com |
| Takeda Pharmaceutical Co Ltd | View profile | 49095 | 1-1, Nihonbashi-Honcho 2-Chome, Chuo-ku, Tokyo, Japan, 103-8668 | https://www.takeda.com |
| CSL Ltd | View profile | 32000 | 655 Elizabeth Street, Melbourne, VIC, Australia, 3000 | https://www.csl.com |
North America hereditary angioedema therapeutics market outlook
The databook is designed to serve as a comprehensive guide to navigating this sector. The databook focuses on market statistics denoted in the form of revenue and y-o-y growth and CAGR across the globe and regions. A detailed competitive and opportunity analyses related to hereditary angioedema therapeutics market will help companies and investors design strategic landscapes.
Kallikrein inhibitor was the largest segment with a revenue share of 52.06% in 2025. Horizon Databook has segmented the North America hereditary angioedema therapeutics market based on c1-inhibitor concentrates, bradykinin b2 receptor antagonist, kallikrein inhibitor covering the revenue growth of each sub-segment from 2021 to 2033.
North America held the largest market share in the global hereditary angioedema therapeutics market, owing to the local presence of major market players, developed infrastructure, and increasing awareness and research programs for the condition.
Hereditary Angioedema (HAE) is a life-threatening genetic disorder, with recent years witnessing the launch or development of novel therapeutics. For instance, in September 2021, Cycle Pharmaceuticals announced the launch of SAJAZIRTM (icatibant) Injection, a novel treatment for HAE.
In addition, the presence of government initiatives and privately funded research institutions in the region are propelling the R&D of novel therapeutics. For instance, the National Center for Advancing Translational Sciences (NCATS) is entirely dedicated to esoteric testing for the cure and treatment of rare diseases.
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Horizon Databook provides a detailed overview of continent-level data and insights on the North America hereditary angioedema therapeutics market, including forecasts for subscribers. This continent databook contains high-level insights into North America hereditary angioedema therapeutics market from 2021 to 2033, including revenue numbers, major trends, and company profiles.
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North America hereditary angioedema hae therapeutics market size, by country, 2021-2033 (US$M)
North America Hereditary Angioedema Therapeutics Market Share, 2025 & 2033 (US$M)
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