High Resolution Melting Analysis Market Size, Share & Trends Analysis Report By Product (Instruments, Reagents, Software), By Application (Mutation Scanning, Zygosity Testing), By End-use, By Region, And Segment Forecasts, 2023 - 2030

Market Size & Trends

The global high resolution melting analysis market size was valued at USD 292.4 million in 2022 and is expected to grow at a compound annual growth rate (CAGR) of 3.32% from 2023 to 2030. Mutation scanning, developing epigenetic applications, and increasing R&D spending are some of the drivers driving the market expansion. The rise in infectious diseases and genetic disorders is the main driver of the market's expansion. According to the WHO, since 2000, the prevalence of infectious diseases has steadily decreased. However, in 2019, they were still directly or indirectly responsible for more than 10.2 million deaths, or 18% of the total number. HRM analysis market development is prompted by benefits such as the lack of probes, prevention of post-PCR contamination of samples, closed tube systems, and high accuracy of melting profile analysis.

Food analysis uses high-resolution melting (HRM) analysis, particularly in identifying and detecting foodborne pathogens. Salmonella, escherichia coli (E. coli), listeria monocytogenes, and campylobacter are some foodborne pathogens that can be quickly and sensitively detected using HRM analysis. HRM analysis can locate these pathogens in food samples by focusing on particular DNA sequences that are particular to them. The method's benefits include high sensitivity, specificity, and speed, which enable prompt detection of tainted food products.

Analyzing barcodes with high resolution melting (Bar-HRM) is a useful molecular method for verifying and inspecting medicinal plants. It makes it possible to identify plant species quickly and precisely using their DNA barcodes, safeguarding the purity of herbal products and spotting adulteration. Bar-HRM analysis helps to monitor and control the harvesting of endangered species, which assists conservation efforts.

The analysis also makes it easier to conduct research and development in medicinal plants, making it possible to identify new species, investigate genetic diversity, and look into phylogenetic links. Bar-HRM analysis can also be used forensically to identify species existence and adulteration in herbal products to ensure safety and regulatory compliance.

During the COVID-19 pandemic, the high-resolution melting (HRM) analysis market contributed substantially. Techniques for HRM analysis were applied to several facets of the pandemic response. Through their assistance in diagnostic tests and surveillance initiatives, they have been instrumental in the timely and accurate diagnosis of the SARS-CoV-2 virus. The detection of genetic variants and mutations in the virus by HRM-based assays has aided the study of the virus's transmission patterns and virulence.

The creation and validation of molecular tests and vaccines have also benefited from using HRM analysis, advancing research and development efforts. The adaptability and dependability of HRM analysis have assisted in addressing COVID-19 by providing useful instruments for testing, research, and monitoring. However, the pandemic also slowed down clinical trials of HRM analysis. Many clinical trials were postponed or delayed due to safety concerns and difficulties in recruiting participants during this period.

Application Insights

The detection of acquired mutations/mutation scanning/SNP typing segment held a significant revenue share in 2022 and the segment is also expected to advance at a significant CAGR over the forecast period. SNP genotyping is a method for examining differences in genomic sequence. In most cases, real-time PCR, microarrays, or next-generation sequencing (NGS) methods are used to find these single-base alterations.

The treatment of numerous chronic and fatal diseases has been revolutionized by clinical research, which has increased public demand for precision medicine. As a result of the development of these treatments that correspond with the patient's genomic structure, which firstly needs analyzing the patient's genome sequence, a whole new application area for SNP genotyping has emerged.

The prevalence of new infectious, chronic, and other diseases is also expected to increase, promoting market expansion. According to the GLOBOCAN 2020 report, which examined the incidence and mortality of 36 cancers in 185 countries worldwide, there were around 10 million cancer-related deaths and 19.3 million new cancer cases globally. Therefore, HRM analysis is anticipated to grow in the coming years due to the advancement of genomes and SNP genotyping techniques.

The epigenetics/methylation profiling and drug-resistant segment will show significant growth during the forecast period in the high resolution melting analysis market. The role of gene expression regulation, DNA methylation patterns, and drug resistance in diverse diseases was found to be facilitated by the use of epigenetics, methylation profiling, and HRM analysis.

Epigenetic alterations, including DNA methylation variations, have been related to diseases like cancer, cardiovascular disorders, neurological ailments, and autoimmune diseases, making them interesting targets for therapeutic and diagnostic breakthroughs. Methylation profiling enables the discovery of disease-specific methylation patterns, allowing early detection, categorization, prognosis, and therapy response prediction in cancer and other diseases.

Product Insights

The instrument segment accounted for a significant revenue share in 2022. A low-cost, one-step, closed-tube procedure, HRM analysis uses real-time PCR instruments to examine DNA sequence variation. For instance, in 2017, Bibby Scientific Ltd.’s brand Stuart, a prominent UK manufacturer of bench-top laboratory equipment, unveiled the SMP50. This innovative automatic melting point system is equipped with high-resolution video technology and an intelligent melt algorithm, enabling it to determine the melting point of up to three samples simultaneously with automated precision.

The software segment is expected to grow significantly during the forecast period. The HRM analysis software generally used are LightCycler 480 Gene Scanning Software by Roche Diagnostics and high-resolution melting (HRM) analysis software v2.0, software v3.0.1, software v1.0, & software v3.1 by Thermo Fisher Scientific. Rising awareness regarding the limitations of conventional systems compared to HRM in real-time and thermos optical analysis are key factors expected to reinforce high-resolution melting market growth positively.

For instance, in 2022, Applied Biosystems, a Thermo Fisher Scientific brand, launched the ABI Prism 7900HT HRM Software. The software is designed for use with the ABI Prism 7900HT real-time PCR system. It includes several features for analyzing HRM data, including automatic baseline correction, melting curve fitting, and statistical analysis.

End-use Insights

The academic research segment held the largest revenue share of over 67% in 2022. The segment growth is attributed to the growing demand for simple & efficient molecular diagnostics and technological advancements from traditional genotyping using labeled probes for high-resolution melt analysis techniques. Moreover, the rising demand for fast and powerful genotype analysis of larger samples for massive-scale genotyping projects is expected to positively reinforce the demand for the HRM analysis market over the forecast period.

High growth opportunities in biotechnology research, well-established reimbursement policies, growing government investments in academic institutions, and favorable regulatory frameworks are key factors fueling the growth of the academic research segment. According to the Organisation for Economic Co-operation and Development (OECD), there has been a significant growth in the number of patents issued in the field of biotechnology due to the importance of intellectual property and development in developments in the fields of molecular biology, biotechnology, and medicine, which is expected to increase demand for HRM products in the academic research segment.

Clinical diagnostics is anticipated to be the fastest-growing segment, with a CAGR of 4.6% through 2030. Growing laboratory automation is one of the primary reasons for the rapid growth of this segment. For instance, Biosero develops automated liquid handling systems for labs. The company's systems are designed to be high-throughput and accurate, and they can be used to automate various tasks, including sample preparation, drug discovery, and clinical diagnostics. As per an announcement from Massachusetts General Hospital, new preventative genomics clinics opened in March 2020. These clinics help patients use their genetic information to understand, prevent, and forecast diseases.

Regional Insights

North America dominated the market and accounted for the largest revenue share of over 45% in 2022. Key factors attributed to market growth in the region include a high investment in research and development, high-quality healthcare infrastructure, the prevalence of genetic and infectious diseases in the region, better reimbursement options, and technological advancements.

In 2022, the American Cancer Society predicted that 1.9 million new cancer cases would be diagnosed nationwide. As of 2022, more than 16.9 million Americans were still alive and had a history of cancer. The demand for HRM analysis is anticipated to expand, primarily fueling market expansion, as cancer incidence increases nationwide. Furthermore, high awareness about different diagnostic tools available and associated benefits are key to overall HRM analysis market growth.

Asia Pacific is expected to expand at the fastest CAGR of 4.4% over the forecast period. Key factors include the high population growth and the increasing number of cancer cases and other chronic diseases leading to high unmet medical needs in the region. Furthermore, the growth of this region's overall in vitro diagnostics market is expected to serve as a high-impact rendering driver over the forecast period.

According to Universitas Indonesia, the top five cancer types in Indonesia in 2020 were breast, cervical, lung, colorectal, and liver. New cases increased by 13.8% compared to the number of new cases in 2018 in the country. In July 2022, Indonesia's Minister of Health introduced the HRM analytical molecular diagnosis kit for colorectal cancer produced by Bio Farma.

Key Companies & Market Share Insights

The HRM analysis market is oligopolistic, with few companies accounting for maximum share. Manufacturers of HRM analysis devices face fierce competition and are focused on enhancing their customer pool through inorganic and organic growth. For instance, Thermo Fisher Scientific Inc.'s High-Resolution Melt Software v3.2 instantly applies default or preset analysis parameters when opening an experiment file, enabling users to get results with little effort. A brand-new Analysis Settings Library is included, enabling users to store optimized settings and quickly access them for use in subsequent trials.

High Resolution Melting Analysis Market Report Scope

Global High Resolution Melting Analysis Market Report Segmentation

This report forecasts revenue growth at the global, regional, and country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2018 to 2030. For the purpose of this study, Grand View Research has segmented the global high resolution melting analysis market report on the basis of product, application, end-use, and region:

• Product Outlook (Revenue, USD Million, 2018 - 2030)

  • Reagents

  • Instruments

  • Software

• Application Outlook (Revenue, USD Million, 2018 - 2030)

  • Detection of Acquired Mutations/Mutation Scanning/SNP Typing

  • Microbial Species Identification

  • Zygosity Testing

  • Epigenetics/Methylation Profiling and Drug-Resistant

• End-use Outlook (Revenue, USD Million, 2018 - 2030)

  • Academic Research

  • Clinical Diagnostics

• Regional Outlook (Revenue, USD Million, 2018 - 2030)

  • North America

    • U.S.

    • Canada

  • Europe

    • UK

    • Germany

    • France

    • Italy

    • Spain

    • Denmark

    • Sweden

    • Norway

  • Asia Pacific

    • Japan

    • China

    • India

    • Australia

    • Thailand

    • South Korea

  • Latin America

    • Brazil

    • Mexico

    • Argentina

  • Middle East and Africa

    • South Africa

    • Saudi Arabia

    • UAE

    • Kuwait