High Resolution Melting Analysis Market Size, Share & Trends Analysis Report By Product (Instruments), By Application (Mutation Scanning, Epigenetics), By End-use (Academic Research), By Region, And Segment Forecasts, 2025 - 2030

Report Overview

The global high resolution melting analysis market size was valued at USD 320.7 million in 2024 and is expected to grow at a CAGR of 2.7% from 2025 to 2030. Mutation scanning, developing epigenetic applications, and increasing R&D spending are some of the drivers driving the market expansion. The rise in infectious diseases and genetic disorders is the main driver of the market's expansion. In addition, technological advancements in HRM platforms, increasing demand for precise genotyping and mutation scanning, and the growing prevalence of genetic disorders. Furthermore, the transition to personalized medicine, rising R&D investments, and regulatory support contribute to market growth.

High-Resolution Melting Analysis (HRM) is a sophisticated molecular biology technique used to identify genetic variations by monitoring the melting behavior of DNA as it is heated. This method is pivotal in detecting mutations, single nucleotide polymorphisms, and epigenetic modifications. As the healthcare sector shifts towards personalized medicine, the demand for precise genetic testing has increased, driving the growth of the HRM market. The rising acceptance of genetic testing globally is supported by advancements in molecular biology and the decreasing costs of genomic sequencing technologies, making HRM more accessible for healthcare providers.

Food analysis uses high-resolution melting (HRM) analysis, particularly in identifying and detecting foodborne pathogens. Salmonella, escherichia coli (E. coli), listeria monocytogenes, and campylobacter are some foodborne pathogens that can be quickly and sensitively detected using HRM analysis. HRM analysis can locate these pathogens in food samples by focusing on particular DNA sequences that are particular to them. The method's benefits include high sensitivity, specificity, and speed, which enable prompt detection of tainted food products.

Analyzing barcodes with high resolution melting (Bar-HRM) is a useful molecular method for verifying and inspecting medicinal plants. It makes it possible to identify plant species quickly and precisely using their DNA barcodes, safeguarding the purity of herbal products and spotting adulteration.

In addition, the integration of new software and equipment facilitates better data management and analysis capabilities, propelling the market forward. Moreover, the integration of HRM into everyday diagnostic tasks is supported by a global shift towards preventive and predictive healthcare, which heavily relies on effective genetic analysis methods.

Furthermore, increased investments from both government and private sectors aim to enhance research infrastructure for molecular diagnostics. This funding supports the development of more robust HRM methodologies and promotes collaborative research projects exploring diverse applications of HRM technology. As a result, HRM is increasingly recognized as a viable solution for various diagnostic challenges, further diversifying its applications in genomic research and personalized healthcare.

Product Insights

The instrument segment led the market and accounted for the largest revenue share of 40.0% in 2024. This growth is attributed to the increasing demand for precise and efficient diagnostic tools, particularly in personalized medicine and molecular diagnostics. In addition, the rising prevalence of chronic diseases and genetic disorders fuels the need for advanced equipment. Furthermore, technological advancements and integration of new software enhance the accuracy and workflow efficiency of these instruments.

The software segment is expected to grow at a CAGR of 4.7% over the forecast period. Rising awareness regarding the limitations of conventional systems compared to HRM in real-time and thermos optical analysis are key factors expected to reinforce high-resolution melting market growth positively. In addition, the segment's growth is propelled by technological advancements that improve data management and analysis capabilities. Growing research initiatives and funding support the development of more sophisticated software solutions, facilitating better interpretation of melting curve data and expanding applications in fields such as oncology and infectious diseases.

Application Insights

The detection of acquired mutations/mutation scanning/SNP typing segment held a highest revenue share of 41.6% in 2024. SNP genotyping is a method for examining differences in genomic sequence. In most cases, real-time PCR, microarrays, or next-generation sequencing (NGS) methods are used to find these single-base alterations. The treatment of numerous chronic and fatal diseases has been revolutionized by clinical research, which has increased public demand for precision medicine. As a result of the development of these treatments that correspond with the patient's genomic structure, which firstly needs analyzing the patient's genome sequence, a whole new application area for SNP genotyping has emerged.

The epigenetics/methylation profiling and drug-resistant segment is expected to grow at a CAGR of 2.6% over the forecast period in the high resolution melting analysis industry. The role of gene expression regulation, DNA methylation patterns, and drug resistance in diverse diseases was found to be facilitated by the use of epigenetics, methylation profiling, and HRM analysis. Epigenetic alterations, including DNA methylation variations, have been related to diseases such as cancer, cardiovascular disorders, neurological ailments, and autoimmune diseases, making them interesting targets for therapeutic and diagnostic breakthroughs. Methylation profiling enables the discovery of disease-specific methylation patterns, allowing early detection, categorization, prognosis, and therapy response prediction in cancer and other diseases.

End Use Insights

The academic research segment held the dominant position in the global high resolution melting analysis industry with the highest revenue share of 69.8% in 2024. The segment growth is attributed to the growing demand for simple & efficient molecular diagnostics and technological advancements from traditional genotyping using labeled probes for high-resolution melt analysis techniques. Moreover, the rising demand for fast and powerful genotype analysis of larger samples for massive-scale genotyping projects is expected to positively reinforce the demand for the HRM analysis market over the forecast period. According to the Organization for Economic Co-operation and Development (OECD), there has been a significant growth in the number of patents issued in the field of biotechnology due to the importance of intellectual property and development in developments in the fields of molecular biology, biotechnology, and medicine, which is expected to increase demand for HRM products in the academic research segment.

Clinical diagnostics is expected to be the fastest-growing segment, with a CAGR of 3.1% from 2025 to 2030. Growing laboratory automation is one of the primary reasons for the rapid growth of this segment. The shift towards personalized medicine and preventive healthcare paradigms enhances demand for HRM technology. For instance, Illumina's India Genomics Summit, held in August 2024, announced the establishment of a Global Capability Center in Bengaluru. This expansion aims to enhance genomics capabilities, supporting global customers and advancing healthcare in India. By 2025, it will employ over 200 professionals, contributing to the global high-resolution melting analysis market by improving diagnostic tools and patient care. Furthermore, its application in detecting mutations and epigenetic changes supports early disease detection and treatment monitoring, making it a crucial tool in clinical settings.

Regional Insights

North America high resolution melting analysis market dominated the global market and accounted for the largest revenue share of 36.0% in 2024. Key factors attributed to market growth in the region include a high investment in research and development, high-quality healthcare infrastructure, the prevalence of genetic and infectious diseases in the region, better reimbursement options, and technological advancements. According to American Cancer Society, more than 2 million new cancer cases are estimated to be detected in the US in 2025, exclusive of non-melanoma skin cancers. As of 2024, more than 18 million Americans with a history of invasive cancer were alive. The demand for HRM analysis is anticipated to expand, primarily fueling market expansion, as cancer incidence increases nationwide. Furthermore, high awareness about different diagnostic tools available and associated benefits are key to overall HRM analysis market growth.

U.S. High Resolution Melting Analysis Market Trends

The high resolution melting analysis market in the U.S led the North American market and held for the largest revenue share in 2024, driven by advancements in precision medicine and strong R&D investments. FDA approvals for treatments tailored to specific genomic profiles fuel demand. In addition, the rising prevalence of genetic disorders also supports HRM technology adoption. Furthermore, the well-established healthcare infrastructure and high-quality research facilities contribute to market growth, making the U.S. a leading hub for HRM applications.

Asia Pacific High Resolution Melting Analysis Market Trends

Asia Pacific high resolution melting analysis market is expected to expand at the fastest CAGR of 4.9% over the forecast period, owing to the high population growth and the increasing number of cancer cases and other chronic diseases leading to high unmet medical needs in the region. Furthermore, the growth of this region's overall in vitro diagnostics market is expected to serve as a high-impact rendering driver over the forecast period. Moreover, increasing awareness of personalized medicine and government initiatives to enhance healthcare systems support the adoption of HRM technology across the region.

The high resolution melting analysis market in Japan dominated the Asia Pacific market, driven by its aging population and the need for advanced diagnostic tools. In addition, strong technological innovation and high-quality healthcare infrastructure support HRM adoption. Furthermore, government initiatives enhance genetic research capabilities, focusing on precision medicine and early disease detection.

Europe High Resolution Melting Analysis Market Trends

Europe high resolution melting analysis marketis expected to witness a significant growth over the forecast period, primarily driven bya high prevalence of chronic diseases and significant genomics research investments. The well-established healthcare system and regulatory support for innovative diagnostics contribute to market expansion. Furthermore, collaborative research projects across European countries enhance the application of HRM in various medical fields, such as oncology and infectious diseases.

The high resolution melting analysis market in Germany led the European market with the highest revenue share in 2024, driven by its robust research environment and strong pharmaceutical industry. In addition, emphasis on precision medicine and genetic diagnostics supports HRM adoption. Furthermore, Germany's role in advancing genomics research and its focus on innovative healthcare solutions position it as a key player in the European HRM market, contributing to advancements in diagnostic technologies.

Key High Resolution Melting Analysis Company Insights

Key players in the high-resolution melting analysis industry include F. Hoffman-La Roche Ltd., Bio Farma, QIAGEN, and others. These companies adopt strategic approaches to maintain competitiveness. These include differentiating themselves through superior product quality and customer service, enhancing their product portfolios to meet diverse needs, and investing in research and development to improve technology and expand applications across various medical fields. Furthermore, strategic partnerships and collaborations are pursued to leverage expertise and resources, further driving market growth and innovation.

• Thermo Fisher Scientific operates in the life sciences segment, manufacturing a wide range of products including real-time PCR systems, specialized software for high-resolution melting analysis, and various laboratory equipment such as mass spectrometers and next-generation sequencers. The company also provide research chemicals, bioreagents, and consumables for molecular biology applications. Their products support genetic variation detection and are used in fields such as cancer diagnostics and infectious disease research.

• Bio-Rad Laboratories operates in the life sciences and diagnostics segment, manufacturing products that support molecular biology and diagnostics indirectly through its PCR systems, gel electrophoresis equipment, and immunoassay systems. Bio-Rad's products facilitate genetic research and diagnostics, contributing to the broader field of molecular biology and genomics. They also offer a range of reagents and consumables for various laboratory applications.

High Resolution Melting Analysis Market Report Scope

Global High Resolution Melting Analysis Market Report Segmentation

This report forecasts revenue growth at global, regional, and country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2018 to 2030. For this study, Grand View Research has segmented the global high resolution melting analysis market report based on product, application, end use, and region:

• Product Outlook (Revenue, USD Million, 2018 - 2030)

  • Instruments

  • Reagents

  • Software

• Application Outlook (Revenue, USD Million, 2018 - 2030)

  • Detection of Acquired Mutations/Mutation Scanning/SNP Typing

  • Microbial Species Identification

  • Zygosity Testing

  • Epigenetics/Methylation Profiling and Drug-Resistant

• End Use Outlook (Revenue, USD Million, 2018 - 2030)

  • Academic Research

  • Clinical Diagnostics

• Regional Outlook (Revenue, USD Million, 2018 - 2030)

  • North America

    • U.S.

    • Canada

    • Mexico

  • Europe

    • Germany

    • UK

    • France

    • Italy

    • Spain

    • Denmark

    • Sweden

    • Norway

  • Asia Pacific

    • Japan

    • China

    • India

    • South Korea

    • Australia

    • Thailand

  • Latin America

    • Brazil

    • Argentina

  • Middle East & Africa

    • South Africa

    • Saudi Arabia

    • UAE

    • Kuwait