Fluorescence In Situ Hybridization Imaging Systems Market Size, Share & Trends Analysis Report By Product (Instruments), By Application (Cancer Diagnosis), By End Use, By Region, And Segment Forecasts, 2024 - 2030

Market Size & Trends

The global fluorescence in situ hybridization imaging systems market size was valued at USD 1.21 billion in 2023 and is projected to grow at a CAGR of 8.4% from 2024 to 2030. The increasing demand for advanced tools in molecular genetics and cytogenetics and the increasing prevalence of cancer, genetic syndromes, genetic anomalies, and other target disorders are some of the driving factors for the fluorescence in situ hybridization imaging systems market to grow in the forecast period. It provides high-resolution images aiding in the detection of subtle genetic changes, enabling early diagnosis of diseases and personalized treatment approaches, leading to an increasing adoption rate and helping the market to grow exponentially.

fluorescence in situ hybridization (FISH) imaging systems have the ability to work with various sample types and act as a significant tool in both research and clinical settings, assisting in identifying genetic markers associated with diseases such as congenital diseases, leukemia and many other such diseases. With the advancements of technology its application in various disease treatments has been possible, thus driving the market positively. For instance, according to a research conducted by National Center for Biotechnology Institute (NCBI) in August 2022, fluorescence in situ hybridization imaging systems assisted by fluorescence microscope was used for the detection of Her2 gene in breast cancer patients.

Ease of usage, greater probe labeling efficiency, positive research outcomes, and reduced procedural time are the advantages of FISH imaging systems, and this is expected to boost demand in the market, thereby helping the growth of the market. The advent of 3D FISH technology is considered a major advancement responsible for driving the market growth. This technology helps in visualizing chromosome territories, single genes, and chromosome subregions, enabling the analysis of both the DNA and proteins in the same 3D preserved sample. Its high sensitivity, specificity, resolution, and preservation of the spatial positions of chromosomes, genes and RNA transcripts help visualize and map genetic material.

FISH imaging systems help view complex genomic structures and help in studying their functions in various biological processes. This advancement has facilitated real-time analysis of fluctuations in disease progression. For instance,-according to a research published by National Center for Biotechnology Institute (NCBI) in April 2020, FISH imaging systems were used in diagnosis and tailored therapies in solid tumors. It helps in the recognition of gene arrangements which helps in distinguishing pathological diagnosis, thus assisting correctness in diagnosis and impact on the course of therapy and the patient’s prognosis. All these factors combined together have helped the FISH imaging systems market to proliferate in the forecast period.

Product Insights

Instruments dominated the market and accounted for a market share of 43.5% in 2023. It is attributed to its higher cost efficiency, portability and ease of use, thereby helping researchers and pathologists to adopt FISH instruments. The increase in the prevalence of cancer, genetic diseases, and other target disorders has helped adopt FISH technology, thereby impacting the market positively. For instance, according to a report of the International Agency for Research on Cancer, approximately 9.7 million cancer deaths and 20 million new cancer cases occurred in 2022. Automated cell analyzers and microscopes assist in FISH technology as its easy to use and portable, thereby surging the market with its adoption by researchers and scientists.

Services segment is expected to grow at the fastest CAGR during the forecast period. It is attributed due to the need for a more multilayered and complex drug development system. Industry players too have played a major role in reducing overall expenditure due to which they are preferred mainly by scientists and researchers. It is also attributed to increasing outsourcing demand, thereby improving operations and ensuring high adherence to quality standards. For instance- FISH imaging services are essential due to the formulation of new combinations and therapies requiring precision.

Application Insights

Cancer diagnosis accounted for the largest market revenue share of in 2023. This growth can be attributed to the high prevalence of cancer worldwide. For instance, according to the World Health Organization, in 2022, breast cancer caused 670,000 deaths globally. The increasing demand for sensitive, accurate, and rapid diagnosis of cancer is expected to drive the market growth. Various government initiatives have helped create awareness about breast cancer and its diagnosis. This is expected to increase the scope of growth. For instance, in 2023, the Global Breast Cancer Initiative Framework set up a target that aims at saving about 2.5 million lives from breast cancer by 2040.

Genetic disease diagnosis is expected to register the fastest CAGR during the forecast period. The high prevalence of genetic diseases caused by genetic aberration sleads to genetic testing, thereby increasing the growth rate of this market. Various government initiatives are also expected to drive growth in the market. For instance, India launched an initiative called UMMID in 2019, which works towards achieving wellness by promoting the prevention of genetic diseases.

End Use Insights

Diagnostic laboratories accounted for the largest market revenue share in 2023. This is attributed to the rise in research projects for developing several technologies and products for fluorescence in situ hybridization imaging processes. This technique is used for the detection of various cancers, such as leukemia, multiple myeloma, and other chromosomal abnormalities. Cell research has been blooming and is expected to fuel growth. For instance- in December 2019, research was conducted where cell sorting of live bacteria was done using FISH imaging systems. Compared to conventional cytogenetics, these systems have the ability to automatically quantify cell viability and stage of the disease. These advantages are expected to drive the fluorescence in situ hybridization imaging systems market and diagnostic laboratories segment to grow over the forecast period.

Research and academic institutes are expected to grow at a significant rate of 8.1% CAGR during the forecast period. FISH imaging systems help researchers visualize and analyze the localization of specific DNA/RNA sequences, assisting in drug discovery, genomic research, and translational research. In order to understand disease mechanisms, identify therapeutic targets, and develop novel interventions, research and academic institutes have integrated FISH imaging systems for their R&D.

Regional Insights

North America fluorescence in situ hybridization systems market was identified as a lucrative region in this industry. In the U.S., there are approximately 1.9 million new cancer cases identified and 609,360 cancer deaths per year, according to figures released by the American Cancer Society in 2022. These devices provide high-resolution imaging of genetic material, making it easier for scientists and medical professionals to identify gene mutations and genetic abnormalities.

U.S. Fluorescence In Situ Hybridization Imaging Systems Market Trends

In addition, a rise in genetic analysis-related research activities has been brought about by the growing adoption of personalized medicine and increasing demand for FISH imaging equipment. Recent years have also seen a rise in the acceptance of technical developments in FISH imaging equipment, such as increased automation, increased throughput, and improved image analysis software. Consequently, labs and healthcare facilities are better suited to manage greater sample volumes and produce accurate results quickly. This is likely to drive growth in the U.S. fluorescence in situ hybridization imaging systems market.

Asia Pacific Fluorescence In Situ Hybridization Imaging Systems Market Trends

Asia Pacific fluorescence in situ hybridization imaging systems market dominated the market in 2023. The growth of this segment can be attributed to the rising R&D investments and efforts in IVD. This FISH technique helps in detecting genetic disorders and rare diseases. The high prevalence of cancer rates, government initiatives play a major role in improving the medical device industry and its manufacturing. For instance, according to a report of the World Economic Forum in 2023, Asia accounts for 58% of cervical cancer deaths and 45% of all global breast cancer cases worldwide. This surge in cancer cases has impacted the market in a positive way. Developing countries such as India and China support outsourcing services in this region, thereby expanding the market growth in Asia Pacific.

The increasing proportion of the geriatric population and technological advancements to facilitate easy diagnosis of diseases are major drivers for market growth. Government Initiatives, such as the National Policy for Rare Diseases (NPRD), for the treatment of rare disease patients in India, were launched in 2021. FISH has been used to diagnose rare diseases such as Ewing sarcoma, synovial sarcoma, and dermatofibrosarcoma protuberans by detecting specific genetic markers. For instance, the Vysis EWSR1 Break Apart FISH Probe Kit is available to diagnose Ewing sarcoma.

Europe Fluorescence In Situ Hybridization Imaging Systems Market Trends

Europe FISH imaging systems market was identified as a lucrative region in 2023. Europe’s well-developed infrastructure and health care facilities, and scope of R&D have driven the market to grow. The World Bank estimated that in 2022, roughly 22% of Germans will be 65 years of age or older and susceptible to at least one chronic illness. Furthermore, according to GLOBOCAN 2020, the prevalence of lung, colorectum, prostate, and breast cancers is high in Germany. The demand for diagnostic systems has increased as a result of greater health awareness brought on by the prevalence of cancer and chronic diseases. Fluorescence in-situ hybridization (FISH) imaging technologies are therefore becoming more and more popular in Germany as a result of the country's thriving medical device R&D scene and rising cancer incidence.

MEA Fluorescence In Situ Hybridization Imaging Systems Market Trends

The MEA FISH imaging systems market is anticipated to witness significant growth due to growing public awareness of genetic diseases and cancer. The rising investments in research and development and government initiatives for the treatment of target diseases and breast cancer using the FISH technology in countries such as South Africa are predicted to help drive regional growth. For instance, in 2024, a World Economic Forum report stated that the Siemens Healthineers-backed Global Alliance for Women's Health, an initiative of the World Economic Forum, established a Cervical and Breast Cancer Coalition during the World Health Assembly.

Key Fluorescence In Situ Hybridization Imaging Systems Company Insights

Some of the key companies in the fluorescence in situ hybridization imaging systems include Euroclone SpA, TissueGnostics GmbH, Agilent Technologies Inc, Abnova Taiwan Corp, BioGenex Laboratories Inc. These companies are growing their market revenue by launching new products, collaborations and adopting various other strategies.

• TissueGnostics GmbH is an Austrian-based company providing FISH (Fluorescence in situ hybridization) imaging systems that enable quantifying and detecting specific DNA sequences within cells. It has a global network of distributors, thereby has high market revenue. TissueGnostics offers TissueFAXS, which is designed for brightfield, fluorescence, multispectral, and confocal imaging of tissue sections and cultured cells.

• BioGenex Laboratories Inc. is a U.S.-based company providing Fluorescence In-Situ Hybridization imaging systems. It offers various FISH products and solutions, such as eFISH Visualization Kits and eFISH Probes for detecting target DNA /RNA sequences. It has a global network of distributors that make FISH products accessible to researchers, clinicians, and diagnostic laboratories worldwide.

Recent Developments

• In April 2023, ANGLE plc entered into a partnership with Bio-View Ltd to develop a liquid biopsy circulating tumor cell (CTC) HER2 assay that can be used for the diagnosis of breast cancer.

• In March 2021, Vizgen launched Merscope, an integrated in situ imaging platform. Merscope is a multiplexed error-robust fluorescence in situ hybridization (MERFISH) technology that can help advance cellular and molecular biology research.

• In June 2018, Agilent Technologies, Inc. expanded its portfolio of probes for In Situ Hybridization (ISH), including FISH, thereby increasing its market share revenue.

Fluorescence In Situ Hybridization Imaging Systems Market Report Scope

Global Fluorescence In Situ Hybridization Imaging Systems Market Report Segmentation

This report forecasts revenue growth at global, regional, and country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2018 to 2030. For this study, Grand View Research has segmented the fluorescence in situ hybridization imaging systems market report based on product, application, end use, and region. 

• Product Outlook (Revenue, USD Million, 2018 - 2030)

  • Instruments

    • Microscopes

    • Automated Cell Analyzers

    • Others

  • Consumables & Accessories

  • Services

  • Software

• Application Outlook (Revenue, USD Million, 2018 - 2030)

  • Cancer Diagnosis

    • Lung Cancer

    • Breast Cancer

    • Others

  • Genetic Disease Diagnosis

  • Others

• End Use Outlook (Revenue, USD Million, 2018 - 2030)

  • Diagnostic Laboratories

  • Research & Academic Institutes

  • Others

• Regional Outlook (Revenue, USD Million; 2018 - 2030)

  • North America

    • U.S.

    • Canada

    • Mexico

  • Europe

    • UK

    • Germany

    • France

    • Italy

    • Spain

    • Denmark

    • Sweden

    • Norway

  • APAC

    • Japan

    • China

    • India

    • Australia

    • South Korea

    • Thailand

  • Latin America

    • Brazil

    • Argentina

  • MEA

    • South Africa

    • Saudi Arabia

    • UAE

    • Kuwait